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Articles Published Processes
2/9/2026 7:34:05 AM | Browse: 59 | Download: 103
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Received |
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2025-06-23 10:44 |
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Peer-Review Started |
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2025-06-23 10:44 |
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First Decision by Editorial Office Director |
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2025-07-30 08:00 |
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Return for Revision |
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2025-07-30 08:00 |
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Revised |
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2025-08-01 06:11 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-17 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-17 08:19 |
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Articles in Press |
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2025-12-17 08:19 |
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Edit the Manuscript by Language Editor |
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2025-12-22 22:51 |
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Typeset the Manuscript |
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2026-02-02 07:39 |
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Publish the Manuscript Online |
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2026-02-09 07:34 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Minireviews |
| Article Title |
Ryanodine receptor 2 mutations in catecholaminergic polymorphic ventricular tachycardia: From molecular mechanisms to precision medicine
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Vaibhav Sharma |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Vaibhav Sharma, MD, Researcher, Internal Medicine, Medstar Washington Hospital Center, Washington, District of Columbia 20010, United States. vsharma3090@gmail.com |
| Key Words |
Ryanodine receptor 2 mutations; Catecholaminergic polymorphic ventricular tachycardia; Precision medicine; Calcium signaling; Genetic cardiology; Arrhythmia management; Sudden cardiac death |
| Core Tip |
Catecholaminergic Polymorphic Ventricular Tachycardia serves as a paradigm of precision cardiology, where a mechanistic unravelling of the ryanodine receptor 2-mediated Calcium ion channel abnormality helps in formulating a genotype-oriented treatment approach. Recent studies regarding the pathopharmacology of store overload-induced Calcium ion release, together with mitochondrial interactions, posit the possibility of a more complex pathophysiology than the classic electrical disorders. Recent milestones in the application of the CRISPR Gene editing tool, together with artificial intelligence-assisted diagnostic techniques in association with a personalized form of pharmacotherapy, have resulted in the successful treatment of 80 to 90% of the affected subjects. |
| Publish Date |
2026-02-09 07:34 |
| Citation |
Sharma V. Ryanodine receptor 2 mutations in catecholaminergic polymorphic ventricular tachycardia: From molecular mechanisms to precision medicine. World J Cardiol 2026; 18(2): 111032 |
| URL |
https://www.wjgnet.com/1949-8462/full/v18/i2/111032.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v18.i2.111032 |
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