| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Molecular insights from skin biopsies: Deciphering microvascular pathology in peripheral vascular diseases
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Maneesha Kumari, Narainder Kumar, Rahol Meghwar, Rahul Rai, FNU Rahul, Muhammad Ali Hassan, Kapeel Kumar, Hanesh Kumar, Muhammad Hashir Naveed Chaudhary, Kainaat Zahid, Farah Alam, Inshal Jawed, Danaish Kumar, Shafaq Jabeen, Umair Qadir and Rabia Asim |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Inshal Jawed, Chief Physician, Senior Researcher, Department of Medicine, Dow University of Health Sciences, Baba-E-Urdu Road, Karachi 75350, Sindh, Pakistan. inshaljwd@gmail.com |
| Key Words |
Peripheral vascular diseases; Skin biopsy; Microvascular pathology; Molecular markers; Histopathology |
| Core Tip |
The systematic review highlights the crucial role of skin biopsies in the diagnosis of peripheral vascular diseases, particularly in terms of histopathological and molecular investigations. The study of skin biopsies is highly informative in understanding diseases in terms of microvascular pathology, endothelial dysfunction, and inflammation, such as systemic sclerosis, diabetic vasculopathy, and vasculitis. The incorporation of molecular markers, such as vascular endothelial growth factor, intercellular adhesion molecule-1, and endothelial nitric oxide synthase, highlights the potential of skin biopsies in enhancing diagnostic accuracy and stratifying patients. Nonetheless, some difficulties related to the standardization of both biopsy and molecular testing remain, which necessitate additional studies to apply it in practice. |
| Publish Date |
2025-12-19 08:32 |
| Citation |
Kumari M, Kumar N, Meghwar R, Rai R, Rahul F, Hassan MA, Kumar K, Kumar H, Chaudhary MHN, Zahid K, Alam F, Jawed I, Kumar D, Jabeen S, Qadir U, Asim R. Molecular insights from skin biopsies: Deciphering microvascular pathology in peripheral vascular diseases. World J Exp Med 2025; 15(4): 111043 |
| URL |
https://www.wjgnet.com/2220-315x/full/v15/i4/111043.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v15.i4.111043 |
