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12/17/2025 6:45:16 AM | Browse: 10 | Download: 16
Publication Name World Journal of Orthopedics
Manuscript ID 111046
Country China
Received
2025-06-24 06:57
Peer-Review Started
2025-06-24 06:57
First Decision by Editorial Office Director
2025-07-14 07:04
Return for Revision
2025-07-14 07:04
Revised
2025-07-28 01:53
Publication Fee Transferred
Second Decision by Editor
2025-11-13 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-11-13 05:59
Articles in Press
2025-11-13 05:59
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-12-08 08:18
Publish the Manuscript Online
2025-12-17 06:45
ISSN 2218-5836 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Orthopedics
Manuscript Type Letter to the Editor
Article Title Biodegradable materials: Applications and advances of magnesium alloys in bone defects
Manuscript Source Invited Manuscript
All Author List Jing-Shun Lu, Zeng-Gao Han, Chen-Yu Song, Min Yang, Yuan-Sheng Huang and Kai-Yang Wang
ORCID
Author(s) ORCID Number
Jing-Shun Lu http://orcid.org/0009-0007-2082-6597
Kai-Yang Wang http://orcid.org/0000-0001-6070-7620
Funding Agency and Grant Number
Corresponding Author Kai-Yang Wang, MD, Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai 200233, China. ortho_wang@163.com
Key Words Bone defects; Biodegradable synthetic materials; Magnesium alloys; Multiple mechanisms; Biocompatibility
Core Tip Degradable magnesium (Mg) alloys have been extensively utilized in the treatment of bone defects owing to their superior mechanical properties, excellent biocompatibility, and potent osteogenic capabilities. Mg alloys enhance bone tissue regeneration via multiple mechanisms, including the bone-nerve circuit, promotion of vascular regeneration, modulation of the immune microenvironment, and upregulation of osteogenic signaling pathways. Additionally, Mg alloys have been engineered into diverse application forms, such as Mg-infused metallic scaffolds and Mg-based bone regeneration membranes. The therapeutic potential of Mg alloys for addressing bone defects warrants further investigation in future studies.
Publish Date 2025-12-17 06:45
Citation

Lu JS, Han ZG, Song CY, Yang M, Huang YS, Wang KY. Biodegradable materials: Applications and advances of magnesium alloys in bone defects. World J Orthop 2025; 16(12): 111046

URL https://www.wjgnet.com/2218-5836/full/v16/i12/111046.htm
DOI https://dx.doi.org/10.5312/wjo.v16.i12.111046
Full Article (PDF) WJO-16-111046-with-cover.pdf
Manuscript File 111046_Auto_Edited_012233.docx
Answering Reviewers 111046-answering-reviewers.pdf
Audio Core Tip 111046-audio.m4a
Conflict-of-Interest Disclosure Form 111046-conflict-of-interest-statement.pdf
Copyright License Agreement 111046-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 111046-non-native-speakers.pdf
Peer-review Report 111046-peer-reviews.pdf
Scientific Misconduct Check 111046-scientific-misconduct-check.png
Scientific Editor Work List 111046-scientific-editor-work-list.pdf
CrossCheck Report 111046-crosscheck-report.pdf