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Articles Published Processes
3/6/2026 8:56:28 AM | Browse: 6 | Download: 14
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Received |
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2025-06-23 12:43 |
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Peer-Review Started |
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2025-06-23 12:53 |
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First Decision by Editorial Office Director |
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2025-07-14 07:42 |
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Return for Revision |
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2025-07-14 07:42 |
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Revised |
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2025-08-08 15:09 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-30 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-30 08:39 |
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Articles in Press |
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2025-10-30 08:39 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-22 09:02 |
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Publish the Manuscript Online |
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2026-03-06 08:56 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Effectiveness of the extensively hydrolyzed formulas in the management of infantile colic: A systematic review and meta-analysis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Konstantinos Dodos, Tsampika-Vasileia Kalamara, Stylianos Xinias, Antigoni Mavroudi, Dorothea Kapoukranidou, Antigoni Sarantaki, Athina Diamanti and Vasiliki E Georgakopoulou |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Vasiliki E Georgakopoulou, MD, Department of Pathophysiology, Laiko General Hospital, Medical School of National and Kapodistrian University of Athens, 17 Agiou Toma Street, Athens 11527, Greece. vaso_georgakopoulou@hotmail.com |
| Key Words |
Infantile colic; Extensively hydrolyzed formulas; Crying duration; Dietary intervention; Formula-fed infants; Cow’s milk protein allergy |
| Core Tip |
Infantile colic is a distressing yet common condition in early infancy. This systematic review and meta-analysis is the first to specifically evaluate the role of extensively hydrolyzed formulas (eHF) in its dietary management. Synthesizing data from six randomized controlled trials, we found that eHF significantly reduces crying duration and improves colic-related symptoms compared to standard formula or pharmacologic interventions. These findings support eHF as an effective and safe dietary option for formula-fed infants with colic, especially in cases where cow's milk protein sensitivity is suspected. |
| Publish Date |
2026-03-06 08:56 |
| Citation |
Dodos K, Kalamara TV, Xinias S, Mavroudi A, Kapoukranidou D, Sarantaki A, Diamanti A, Georgakopoulou VE. Effectiveness of the extensively hydrolyzed formulas in the management of infantile colic: A systematic review and meta-analysis. World J Clin Pediatr 2026; 15(1): 111066 |
| URL |
https://www.wjgnet.com/2219-2808/full/v15/i1/111066.htm |
| DOI |
https://dx.doi.org/10.5409/wjcp.v15.i1.111066 |
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