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Articles Published Processes
11/26/2025 3:57:03 AM | Browse: 9 | Download: 12
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Received |
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2025-06-23 01:11 |
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Peer-Review Started |
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2025-06-23 01:11 |
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First Decision by Editorial Office Director |
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2025-07-15 08:02 |
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Return for Revision |
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2025-07-15 08:02 |
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Revised |
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2025-07-31 08:34 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-09-29 06:28 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-09 07:51 |
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Articles in Press |
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2025-10-09 07:51 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-20 02:14 |
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Publish the Manuscript Online |
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2025-11-26 03:57 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Review |
| Article Title |
Unravelling the reversion mechanisms of activated hepatic stellate cell properties by extracellular vesicles from mesenchymal stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Md Ariful Islam, Jannatul Mawya, Umme Salma, Noor Hayaty Abu Kasim and Nazmul Haque |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Nazmul Haque, Chief, Head, PhD, Department of Regenerative Medicine, Concord Stem Cell Limited, 03, Sima Blossom, Road 16, Dhanmondi, Dhaka 1209, Bangladesh. haquen1983@gmail.com |
| Key Words |
Exosomes; MicroRNAs; Myofibroblast; Nuclear factor kappa B; Transforming growth factor-beta |
| Core Tip |
Liver fibrosis and cirrhosis are global health challenges resulting from persistent liver injury, hepatocyte damage, inflammation, and hepatic stellate cell activation. These processes dysregulate key signaling pathways such as transforming growth factor beta/small mother against decapentaplegic, Wnt/β-catenin, nuclear factor-kappa B, and mitogen-activated protein kinase, leading to excessive extracellular matrix deposition. Importantly, once the underlying cause is addressed, liver’s natural ability to regenerate and regress fibrosis is restored. Innovative approaches such as mesenchymal stem cell-derived extracellular vesicles and microRNA-based therapies are gaining attention due to their potential to deliver targeted anti-fibrotic molecules, regulate gene expression, and reverse liver fibrosis. Ultimately, these strategies could lessen the burden of chronic liver diseases globally. |
| Publish Date |
2025-11-26 03:57 |
| Citation |
Islam MA, Mawya J, Salma U, Abu Kasim NH, Haque N. Unravelling the reversion mechanisms of activated hepatic stellate cell properties by extracellular vesicles from mesenchymal stem cells. World J Stem Cells 2025; 17(11): 111090 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i11/111090.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i11.111090 |
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