BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
3/6/2026 8:56:29 AM | Browse: 4 | Download: 17
 |
Received |
|
2025-06-24 06:40 |
|
Peer-Review Started |
|
2025-06-24 06:42 |
|
First Decision by Editorial Office Director |
|
2025-07-15 09:56 |
|
Return for Revision |
|
2025-07-15 09:56 |
|
Revised |
|
2025-07-27 18:44 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2025-11-07 02:37 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2025-11-07 10:08 |
|
Articles in Press |
|
2025-11-07 10:08 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-02-03 00:36 |
|
Publish the Manuscript Online |
|
2026-03-06 08:56 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Efficacy and safety of dual-targeted therapy in children with inflammatory bowel disease: Retrospective cohort study
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Tatiana Gabrusskaya, Natalia Ulanova, Elena Shilova, Natalia Volkova, Sofia Kilina, Elena Kornienko and Mikhail Kostik |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Mikhail Kostik, MD, PhD, Professor, Hospital Pediatry, Saint-Petersburg State Pediatric Medical University, Lytovskaya 2, Saint Petersburg 194100, Sankt-Peterburg, Russia. kost-mikhail@yandex.ru |
| Key Words |
Inflammatory bowel disease; Dual-targeted therapy; Difficult-to-treat patients; Janus kinase inhibitors; Biological drugs; Crohn's disease; Ulcerative colitis |
| Core Tip |
We conducted a single-center retrospective cohort study on 18 children with inflammatory bowel disease who received dual-targeted therapy (DTT) with biologics and Janus kinase inhibitors. Clinical remission was achieved in 9 out of 20 (45%) and 13 out of 20 (65%) DTT courses at three months and six months (M6), respectively. In contrast, laboratory and endoscopic remission were achieved in 8 out of 20 (40%) and 9 out of 17 (53%) treatment courses, respectively, within M6 of treatment initiation. Predictors of poor response to DTT were perianal lesions and upper gastrointestinal tract involvement in Crohn’s disease. Early onset of inflammatory bowel diseases was associated with higher remission rates. |
| Publish Date |
2026-03-06 08:56 |
| Citation |
Gabrusskaya T, Ulanova N, Shilova E, Volkova N, Kilina S, Kornienko E, Kostik M. Efficacy and safety of dual-targeted therapy in children with inflammatory bowel disease: Retrospective cohort study. World J Clin Pediatr 2026; 15(1): 111093 |
| URL |
https://www.wjgnet.com/2219-2808/full/v15/i1/111093.htm |
| DOI |
https://dx.doi.org/10.5409/wjcp.v15.i1.111093 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
