Publication Name	World Journal of Gastroenterology
Manuscript ID	11114
Country	China

Received	2014-05-05 19:11
Peer-Review Started	2014-05-06 00:00
To Make the First Decision	2014-05-29 19:12
Return for Revision	2014-06-04 11:17
Revised	2014-06-21 23:24
Second Decision	2014-09-05 16:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-05 17:07
Articles in Press	2014-09-05 17:24
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-09-19 09:53
Typeset the Manuscript	2014-12-16 21:45
Publish the Manuscript Online	2015-01-06 09:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of interleukin-22 in inflammatory bowel disease
Manuscript Source	Unsolicited Manuscript
All Author List	Lin-Jing Li, Chen Gong, Mei-Hua Zhao and Bai-Sui Feng
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81070288 National Natural Science Foundation of China 81270452 Medical Science and Technology Foundation of Henan Province 201001004 Science and Technology Leader Overseas Training Foundation of Henan Province 201201013
Corresponding Author	Bai-Sui Feng, MD, PhD, Professor, Department of Gastroenterology, the Fifth Affiliated Hospital of Zhengzhou University, 3 Kangfu Front Street, Erqi District, Zhengzhou 450000, Henan Province, China. fbs163@163.com
Key Words	Inflammatory bowel disease; Interleukin-22; Signal transducer and activator of transcription 3
Core Tip	Interleukin (IL)-22 is expressed by adaptive immune system cells and innate lymphocytes. Several cytokines and many transcriptional factors and T regulatory cells can regulate IL-22 expression. Through activation of signal transducer and activator of transcription 3 signaling cascades, IL-22 induces antimicrobial, proliferative and antiapoptotic pathways, which can help fix damaged tissue and promote tissue repair mechanisms. IL-22 is also associated with inflammatory bowel disease (IBD) susceptibility genes that regulate inflammatory responses in tissues. All of these processes play crucial roles in IBD pathogenesis and collectively provide an important rationale for the development of novel therapeutic measures for this disease.
Publish Date	2015-01-06 09:08
Citation	Li LJ, Gong C, Zhao MH, Feng BS. Role of interleukin-22 in inflammatory bowel disease. World J Gastroenterol 2014; 20(48): 18177-18188
URL	http://www.wjgnet.com/1007-9327/full/v20/i48/18177.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i48.18177

Full Article (PDF)	WJG-20-18177.pdf
Full Article (Word)	WJG-20-18177.doc
Manuscript File	11114-Review.doc
Answering Reviewers	11114-Answering reviewers.pdf
Copyright License Agreement	11114-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	11114-Language certificate.PDF
Peer-review Report	11114-Peer review(s).pdf
Scientific Misconduct Check	11114-CrossCheck.jpg
Scientific Editor Work List	11114-Scientific editor work list.pdf