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Articles Published Processes
11/14/2025 12:56:25 AM | Browse: 57 | Download: 315
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Received |
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2025-06-25 06:02 |
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Peer-Review Started |
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2025-06-25 06:02 |
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First Decision by Editorial Office Director |
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2025-07-21 08:56 |
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Return for Revision |
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2025-07-23 15:08 |
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Revised |
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2025-08-15 17:14 |
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Publication Fee Transferred |
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2025-08-21 06:42 |
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Second Decision by Editor |
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2025-10-16 02:53 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-17 06:57 |
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Articles in Press |
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2025-10-17 06:57 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-05 00:54 |
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Publish the Manuscript Online |
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2025-11-14 00:56 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
5’-transfer RNA halve-lysine-CTT as a promising biomarker for early detection of hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jie Yuan, Wen-Chao Gu, Tian-Xin Xu, Xian-Juan Shen, Xian Li, Lei Shen, Yan Zhang and Shao-Qing Ju |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Scientific Research Project of Nantong Municipal Commission of Health and Family Planning |
QN2023001 |
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| Corresponding Author |
Shao-Qing Ju, MD, PhD, Professor, Department of Laboratory Medicine, Affiliated Hospital of Nantong University, No. 20 Xisi Road, Nantong 226001, Jiangsu Province, China. cherrysacrifice@163.com |
| Key Words |
5’-transfer RNA halve-lysine-CTT; Hepatocellular carcinoma; Transfer RNA-derived small RNAs; Transfer RNA-derived fragments; Diagnosis biomarker |
| Core Tip |
Through high-throughput sequencing, we found transfer RNA (tRNA)-derived small RNA differentially expressed in early-stage hepatocellular carcinoma (HCC) tissues. 5’-tRNA halve (tiRNA)-lysine (Lys)-CTT, one of the tRNA-derived small RNAs, had great diagnostic efficacy and potential as new “liquid biopsy” biomarkers for the diagnosis of early stage of HCC. We speculated that 5’-tiRNA-Lys-CTT may be involved in multiple cancer-related signaling pathways, and would like to investigate the specific mechanisms of 5’-tiRNA-Lys-CTT in HCC in future studies. |
| Publish Date |
2025-11-14 00:56 |
| Citation |
Yuan J, Gu WC, Xu TX, Shen XJ, Li X, Shen L, Zhang Y, Ju SQ. 5’-transfer RNA halve-lysine-CTT as a promising biomarker for early detection of hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(11): 111142 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i11/111142.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i11.111142 |
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