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Articles Published Processes
1/12/2026 10:07:37 AM | Browse: 0 | Download: 0
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Received |
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2025-07-01 06:00 |
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Peer-Review Started |
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2025-07-01 06:00 |
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First Decision by Editorial Office Director |
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2025-07-14 03:46 |
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Return for Revision |
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2025-07-14 03:46 |
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Revised |
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2025-07-25 13:22 |
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Publication Fee Transferred |
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2025-07-29 13:58 |
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Second Decision by Editor |
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2025-11-17 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-18 00:06 |
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Articles in Press |
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2025-11-18 00:06 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-04 01:06 |
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Publish the Manuscript Online |
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2026-01-12 10:07 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Sonazoid-contrast-enhanced ultrasound for the histological diagnosis of hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ruo-Bing Liu, Jun-Yi Xin, Zhe Huang and Kai-Yan Li |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Kai-Yan Li, Chief Physician, PhD, Professor, Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Qiaokou District, Wuhan 430030, Hubei Province, China. liky20006@126.com |
| Key Words |
Contrast-enhanced ultrasound; Hepatocellular carcinoma; Quantitative parameters; Kupffer phase; Pathological differentiation |
| Core Tip |
This study used quantitative parameters and imaging characteristics from Sonazoid-contrast-enhanced ultrasound using perfluorobutane microspheres to evaluate the histological differentiation of hepatocellular carcinoma (HCC). Both univariate and multivariate analyses indicated that Kupffer phase parameters, particularly the intensity ratio (IR), outperformed conventional clinical markers. IR proved to be a valuable, non-invasive predictor of tumor differentiation, supporting more informed preoperative decision-making in HCC management. It is simple to calculate, relatively unaffected by variations in hepatic perfusion or fibrosis, and well-suited for routine clinical application. Receiver operating characteristic analysis identified an optimal cut-off value of 1.215 for IR. |
| Publish Date |
2026-01-12 10:07 |
| Citation |
Liu RB, Xin JY, Huang Z, Li KY. Sonazoid-contrast-enhanced ultrasound for the histological diagnosis of hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(1): 111144 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i1/111144.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i1.111144 |
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