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Articles Published Processes
12/26/2025 10:27:29 AM | Browse: 78 | Download: 261
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Received |
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2025-06-24 08:40 |
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Peer-Review Started |
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2025-06-24 08:41 |
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First Decision by Editorial Office Director |
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2025-07-29 09:43 |
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Return for Revision |
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2025-07-31 01:15 |
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Revised |
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2025-08-06 09:48 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-06 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-06 11:40 |
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Articles in Press |
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2025-11-06 11:40 |
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Edit the Manuscript by Language Editor |
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2025-11-09 21:08 |
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Typeset the Manuscript |
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2025-12-18 01:02 |
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Publish the Manuscript Online |
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2025-12-26 10:27 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Histone lactylation: A key epigenetic modulator in the pathogenesis of metabolic dysfunction-associated steatohepatitis and alcoholic steatohepatitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mable Misha Singh, Arunim Shah, Sangam Rajak, Chandra Prakash Chaturvedi and Rohit A Sinha |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Engineering Research Board |
CRG/2022/002149 |
| Indian Council of Medical Research |
ICMR/02/833/IGP-2024, R.12016/12/2023-HR |
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| Corresponding Author |
Rohit A Sinha, Associate Professor, Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareilly Road, Lucknow 226014, Uttar Pradesh, India. anthony.rohit@gmail.com |
| Key Words |
Histone lactylation; Metabolic dysfunction-associated steatohepatitis; Alcoholic steatohepatitis; Epigenetics; Lactate |
| Core Tip |
This review article describes a biological process called histone lactylation and its role in liver diseases. Histone lactylation is a metabolically aligned epigenetic modification on histones which can regulate hepatic gene expression. Increased lactate levels in metabolic dysfunction-associated steatohepatitis and alcoholic steatohepatitis may induce histone lactylation of key genes involved in hepatic lipogenesis, inflammation and fibrosis. Consequently, pharmacological modulation of histone lactylation may open a new therapeutic option to counter metabolic dysfunction-associated steatohepatitis and alcoholic steatohepatitis progression. |
| Publish Date |
2025-12-26 10:27 |
| Citation |
Singh MM, Shah A, Rajak S, Chaturvedi CP, Sinha RA. Histone lactylation: A key epigenetic modulator in the pathogenesis of metabolic dysfunction-associated steatohepatitis and alcoholic steatohepatitis. World J Hepatol 2025; 17(12): 111153
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| URL |
https://www.wjgnet.com/1948-5182/full/v17/i12/111153.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i12.111153 |
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