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Articles Published Processes
12/4/2025 6:40:47 AM | Browse: 89 | Download: 270
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Received |
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2025-06-24 07:47 |
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Peer-Review Started |
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2025-06-24 07:48 |
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First Decision by Editorial Office Director |
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2025-06-27 02:40 |
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Return for Revision |
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2025-06-27 02:40 |
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Revised |
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2025-07-11 02:41 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-22 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-22 08:37 |
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Articles in Press |
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2025-10-22 08:37 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-02 00:58 |
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Publish the Manuscript Online |
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2025-12-04 06:40 |
| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Association between Alzheimer's disease and Porphyromonas gingivalis products in murine models: A systematic review
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Karen L Ochoa, Amy G Heredia, Camila C Piedra, Reymonth J Arias, Bengy J Ortiz and Jose A Dominguez-Gortaire |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jose A Dominguez-Gortaire, Professor, Facultad de Ciencias Biológicas, Universidad Central del Ecuador, Av. Yaguachi y Numa Pompillo, Quito 170403, Pichincha, Ecuador. jadominguezg@uce.edu.ec |
| Key Words |
Periodontal disease; Murine models; Lipopolysaccharides; Neuroinflammation; Gingipains; Porphyromonas gingivalis; Alzheimer’s disease |
| Core Tip |
This review shows the role of Porphyromonas gingivalis (P. gingivalis)-derived products in Alzheimer's disease-like pathology in murine models. Lipopolysaccharides and gingipains were the most implicated bacterial factors, activating glial cells and proinflammatory pathways. These interactions resulted in β-amyloid accumulation, tau hyperphosphorylation, and cognitive impairment. Our analysis highlights the importance of chronic oral infection in the progression of Alzheimer's disease and supports P. gingivalis treatment as a potential preventive strategy. |
| Publish Date |
2025-12-04 06:40 |
| Citation |
Ochoa KL, Heredia AG, Piedra CC, Arias RJ, Ortiz BJ, Dominguez-Gortaire JA. Association between Alzheimer's disease and Porphyromonas gingivalis products in murine models: A systematic review. World J Biol Chem 2025; 16(4): 111156 |
| URL |
https://www.wjgnet.com/1949-8454/full/v16/i4/111156.htm |
| DOI |
https://dx.doi.org/10.4331/wjbc.v16.i4.111156 |
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