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Articles Published Processes
11/26/2025 3:57:03 AM | Browse: 136 | Download: 491
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Received |
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2025-06-25 02:08 |
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Peer-Review Started |
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2025-06-25 02:09 |
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First Decision by Editorial Office Director |
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2025-08-08 08:10 |
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Return for Revision |
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2025-08-08 08:10 |
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Revised |
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2025-08-11 11:35 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-09-19 10:47 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-09 07:40 |
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Articles in Press |
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2025-10-09 07:40 |
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Edit the Manuscript by Language Editor |
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2025-10-20 19:17 |
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Typeset the Manuscript |
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2025-10-31 13:22 |
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Publish the Manuscript Online |
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2025-11-26 03:57 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Targeting adipose remodeling: Synergistic mechanisms of drugs and adipose-derived stem cells in obese type 2 diabetes mellitus
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Cheng Luo, Xian-Mei Yu, Liang-Yan Hua, Mei-Qi Zeng, Hui Xu, Cheng-Zheng Duan, Shi-Yu Xu, Da Sun, Li-Ya Ye and Dong-Juan He |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Special Fund Project for Clinical Medicine of Zhejiang Medical Association |
2024ZYC-Z30 |
| Zhejiang Provincial Traditional Chinese Medicine Science and Technology Program |
2025ZL144 |
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| Corresponding Author |
Dong-Juan He, Chief Physician, Dean, Director, MD, Professor, Department of Endocrinology, The Second People’s Hospital of Quzhou, No. 338 Xin’an Avenue, Qujiang District, Quzhou 324002, Zhejiang Province, China. hedongjuan1247@wmu.edu.cn |
| Key Words |
Adipose-derived stem cells; Fat redistribution; Insulin resistance; Metabolic inflammation; Pioglitazone; Type 2 diabetes mellitus |
| Core Tip |
This review explores how pharmacological agents (pioglitazone, metformin, glucagon-like peptide-1 receptor agonist, sodium-glucose cotransporter-2 inhibitors) and adipose-derived stem cells synergistically remodel dysfunctional adipose tissue in obesity-associated type 2 diabetes. It highlights the roles of adipose browning, mitochondrial restoration, anti-inflammatory paracrine effects, and fat redistribution. By integrating metabolic drug actions with regenerative cell therapies, the review proposes a precision intervention strategy targeting insulin resistance and metabolic inflammation at the tissue level, offering translational insights for individualized treatment of diabetic obesity. |
| Publish Date |
2025-11-26 03:57 |
| Citation |
Luo C, Yu XM, Hua LY, Zeng MQ, Xu H, Duan CZ, Xu SY, Sun D, Ye LY, He DJ. Targeting adipose remodeling: Synergistic mechanisms of drugs and adipose-derived stem cells in obese type 2 diabetes mellitus. World J Stem Cells 2025; 17(11): 111162
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| URL |
https://www.wjgnet.com/1948-0210/full/v17/i11/111162.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i11.111162 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
