| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Targeting adipose remodeling: Synergistic mechanisms of drugs and adipose-derived stem cells in obese type 2 diabetes mellitus
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Cheng Luo, Xian-Mei Yu, Liang-Yan Hua, Mei-Qi Zeng, Hui Xu, Cheng-Zheng Duan, Shi-Yu Xu, Da Sun, Li-Ya Ye and Dong-Juan He |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Special Fund Project for Clinical Medicine of Zhejiang Medical Association |
2024ZYC-Z30 |
| Zhejiang Provincial Traditional Chinese Medicine Science and Technology Program |
2025ZL144 |
|
| Corresponding Author |
Dong-Juan He, Chief Physician, Dean, Director, MD, Professor, Department of Endocrinology, The Second People’s Hospital of Quzhou, No. 338 Xin’an Avenue, Qujiang District, Quzhou 324002, Zhejiang Province, China. hedongjuan1247@wmu.edu.cn |
| Key Words |
Adipose-derived stem cells; Fat redistribution; Insulin resistance; Metabolic inflammation; Pioglitazone; Type 2 diabetes mellitus |
| Core Tip |
This review explores how pharmacological agents (pioglitazone, metformin, glucagon-like peptide-1 receptor agonist, sodium-glucose cotransporter-2 inhibitors) and adipose-derived stem cells synergistically remodel dysfunctional adipose tissue in obesity-associated type 2 diabetes. It highlights the roles of adipose browning, mitochondrial restoration, anti-inflammatory paracrine effects, and fat redistribution. By integrating metabolic drug actions with regenerative cell therapies, the review proposes a precision intervention strategy targeting insulin resistance and metabolic inflammation at the tissue level, offering translational insights for individualized treatment of diabetic obesity. |
| Publish Date |
2025-11-26 03:57 |
| Citation |
Luo C, Yu XM, Hua LY, Zeng MQ, Xu H, Duan CZ, Xu SY, Sun D, Ye LY, He DJ. Targeting adipose remodeling: Synergistic mechanisms of drugs and adipose-derived stem cells in obese type 2 diabetes mellitus. World J Stem Cells 2025; 17(11): 111162 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i11/111162.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i11.111162 |
