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Articles Published Processes
11/28/2025 2:00:44 PM | Browse: 19 | Download: 80
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Received |
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2025-07-07 10:41 |
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Peer-Review Started |
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2025-07-07 10:41 |
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First Decision by Editorial Office Director |
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2025-07-24 08:19 |
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Return for Revision |
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2025-07-24 08:19 |
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Revised |
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2025-08-05 21:25 |
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Publication Fee Transferred |
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2025-08-12 23:36 |
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Second Decision by Editor |
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2025-08-27 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-08-27 07:26 |
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Articles in Press |
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2025-08-27 07:26 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-17 04:06 |
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Publish the Manuscript Online |
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2025-11-28 14:00 |
| ISSN |
2220-3141(online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Critical Care Medicine |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Current and emerging therapeutic options for refractory septic shock: A systematic review
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Flavio Eduardo Nacul, Murilo Borges Bezerra, Brenno Cardoso Gomes, Fábio Barlem Hohmann, Ricardo Esper Treml, Tulio Caldonazo, Arnaldo Alves da Silva, Rogerio H Passos, Neymar Elias de Oliveira, Grazielle Pangratz Bedretchuk and Joao Manoel Silva Jr |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Brenno Cardoso Gomes, Integrated Sciences Service, Universidade Federal do Paraná, R. Padre Camargo, Curitiba 80060-240, Paraná, Brazil. brennogomes@ufpr.br |
| Key Words |
Refractory septic shock; Vasopressors; Adjunctive therapies; Sepsis; Mortality outcome |
| Core Tip |
This systematic review of 24 randomized controlled trials evaluates novel therapies for refractory septic shock, including methylene blue, vasopressin, terlipressin, and hydrocortisone-vitamin C-thiamine combinations. While these interventions improve hemodynamics and organ function, no consistent mortality reduction was observed. Methylene blue reduced vasopressor dependency, and terlipressin enhanced renal perfusion. Larger, standardized trials are needed to validate findings and guide multimodal treatment strategies. |
| Publish Date |
2025-11-28 14:00 |
| Citation |
Nacul FE, Bezerra MB, Gomes BC, Hohmann FB, Treml RE, Caldonazo T, da Silva AA, Passos RH, de Oliveira NE, Bedretchuk GP, Silva Jr JM. Current and emerging therapeutic options for refractory septic shock: A systematic review. World J Crit Care Med 2025; 14(4): 111164 |
| URL |
https://www.wjgnet.com/2220-3141/full/v14/i4/111164.htm |
| DOI |
https://dx.doi.org/10.5492/wjccm.v14.i4.111164 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
