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Articles Published Processes
12/23/2025 6:25:20 AM | Browse: 4 | Download: 1
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Received |
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2025-06-26 04:18 |
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Peer-Review Started |
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2025-06-26 04:18 |
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First Decision by Editorial Office Director |
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2025-08-07 09:28 |
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Return for Revision |
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2025-08-09 13:22 |
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Revised |
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2025-08-14 12:07 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-12 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-13 03:40 |
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Articles in Press |
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2025-11-13 03:40 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-05 08:54 |
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Publish the Manuscript Online |
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2025-12-23 06:25 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Relevance and application of sirtuin 3-activated mitophagy in gastric cancer treatment
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hao-Yu Zhao, Chu-Ying Yu, Xin-Tong Ye, Su-Ting Qian, Ye Huang and Qing-Sheng Liu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Qing-Sheng Liu, Chief Physician, Department of Gastroenterology, Third People's Hospital of Hangzhou, No. 453 Stadium Road, Hangzhou 310009, Zhejiang Province, China. 7394822@qq.com |
| Key Words |
Sirtuin 3; Gastric cancer; Mitochondrial function; Mitophagy; Oxidative stress; Antitumor |
| Core Tip |
Sirtuin 3 (SIRT3), a mitochondrial NAD+-dependent deacetylase, regulates mitophagy via protein acetylation and signaling pathways. Downregulated in gastric cancer (GC), its low expression links to poor prognosis, deeper invasion, and reduced differentiation. SIRT3 enhances mitophagy to alleviate oxidative stress, correct mitochondrial dysfunction, and inhibit GC. Preclinical studies show it synergizes with therapies, boosting efficacy and reducing toxicity. This mini-review covers its mechanisms, therapeutic potential, and prospects for activator/delivery system development. |
| Publish Date |
2025-12-23 06:25 |
| Citation |
Zhao HY, Yu CY, Ye XT, Qian ST, Huang Y, Liu QS. Relevance and application of sirtuin 3-activated mitophagy in gastric cancer treatment. World J Clin Oncol 2025; 16(12): 111175 |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i12/111175.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i12.111175 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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