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1/27/2026 10:12:30 AM | Browse: 0 | Download: 0
Publication Name World Journal of Hepatology
Manuscript ID 111211
Country Singapore
Received
2025-06-26 08:22
Peer-Review Started
2025-06-26 08:26
First Decision by Editorial Office Director
2025-07-21 09:00
Return for Revision
2025-07-21 13:37
Revised
2025-09-02 09:06
Publication Fee Transferred
Second Decision by Editor
2025-12-01 03:10
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-12-02 06:09
Articles in Press
2025-12-02 06:09
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-01-13 03:40
Publish the Manuscript Online
2026-01-27 10:12
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pediatrics
Manuscript Type Minireviews
Article Title Fighting the epidemic of pediatric metabolic dysfunction-associated steatotic liver disease: Role of non-invasive diagnostics and early pharmacological intervention
Manuscript Source Invited Manuscript
All Author List Nicholas Beng-Hui Ng, Andrew Anjian SNG and James Guoxian Huang
ORCID
Author(s) ORCID Number
Nicholas Beng-Hui Ng http://orcid.org/0000-0002-7948-8891
Andrew Anjian SNG http://orcid.org/0000-0002-4176-4774
James Guoxian Huang http://orcid.org/0000-0002-5869-4194
Funding Agency and Grant Number
Corresponding Author James Guoxian Huang, Assistant Professor, Khoo Teck Puat - National University Children's Medical Institute, Department of Paediatrics, National University Health System, 1E Kent Ridge Road NUHS Tower Block Level 12, Singapore 119228, Singapore. paehgj@nus.edu.sg
Key Words Pediatric metabolic dysfunction-associated steatotic liver disease; Glucagon-like peptide 1 receptor agonists; Vibration-controlled transient elastography; Resmetirom; Pediatric obesity
Core Tip The escalating prevalence of pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) mirrors the rise in pediatric obesity. The advent of non-invasive diagnostics may allow for earlier recognition of liver fibrosis, and may prioritize the need for early pharmacological therapy. We propose an updated diagnostic and monitoring algorithm incorporating recent multi-societal statements in pediatric MASLD. The increased use of weight-loss pharmacotherapy such as glucagon-like peptide 1 receptor agonists in adolescent patients has shown efficacy in inducing weight loss, which may have potential in halting MASLD progression if instituted early in the disease course.
Publish Date 2026-01-27 10:12
Citation

Ng NBH, SNG AA, Huang JG. Fighting the epidemic of pediatric metabolic dysfunction-associated steatotic liver disease: Role of non-invasive diagnostics and early pharmacological intervention. World J Hepatol 2026; 18(1): 111211

URL https://www.wjgnet.com/1948-5182/full/v18/i1/111211.htm
DOI https://dx.doi.org/10.4254/wjh.v18.i1.111211
Full Article (PDF) WJH-18-111211-with-cover.pdf
Manuscript File 111211_Auto_Edited_071149.docx
Answering Reviewers 111211-answering-reviewers.pdf
Audio Core Tip 111211-audio.m4a
Conflict-of-Interest Disclosure Form 111211-conflict-of-interest-statement.pdf
Copyright License Agreement 111211-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 111211-non-native-speakers.pdf
Peer-review Report 111211-peer-reviews.pdf
Scientific Misconduct Check 111211-scientific-misconduct-check.png
Scientific Editor Work List 111211-scientific-editor-work-list.pdf
CrossCheck Report 111211-crosscheck-report.pdf