Publication Name	World Journal of Gastroenterology
Manuscript ID	11123
Country	France

Received	2014-05-06 09:31
Peer-Review Started	2014-05-06 21:23
First Decision by Editorial Office Director
Return for Revision	2014-06-15 14:47
Revised	2014-06-30 20:37
Publication Fee Transferred
Second Decision by Editor	2014-09-05 16:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-09-05 17:07
Articles in Press	2014-09-05 17:24
Edit the Manuscript by Language Editor	2014-11-17 21:52
Typeset the Manuscript	2014-12-18 14:55
Publish the Manuscript Online	2015-01-06 09:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-1 signaling
Manuscript Source	Unsolicited Manuscript
All Author List	Emilien Loeuillard, Julien Bertrand, Anni Herranen, Chloé Melchior, Charlène Guérin, Moïse Coëffier, Moutaz Aziz, Pierre Déchelotte, Guillaume Savoye and Rachel Marion-Letellier
Funding Agency and Grant Number
Corresponding Author	Rachel Marion-Letellier, PhD, INSERM Unit UMR1073, Rouen University and Rouen University Hospital, 22, Boulevard Gambetta, Rouen Cedex 76183, France. marion_rachel@hotmail.com
Key Words	Bortezomib; Colitis; Fibrosis; Proteasome
Core Tip	Inflammatory bowel disease gives rise to challenging clinical conditions, and many patients have to undergo surgery throughout their life due to irreversible lesions. As no specific treatment is currently available for intestinal fibrosis, we tested an antifibrotic drug that is effective in other chronic inflammatory diseases. In the present study, we found that rats with 2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis exhibited colon fibrosis associated with high expression of transforming growth factor-? signaling, particularly in the Akt pathway. Nevertheless, we failed to inhibit colon fibrosis by proteasome inhibition in our experimental conditions.
Publish Date	2015-01-06 09:08
Citation	Loeuillard E, Bertrand J, Herranen A, Melchior C, Guérin C, Coëffier M, Aziz M, Déchelotte P, Savoye G, Marion-Letellier R. 2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-b1 signaling. World J Gastroenterol 2014; 20(48): 18207-18215
URL	http://www.wjgnet.com/1007-9327/full/v20/i48/18207.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i48.18207

Full Article (PDF)	WJG-20-18207.pdf
Full Article (Word)	WJG-20-18207.doc
Manuscript File	11123-Review.docx
Answering Reviewers	11123-Answering reviewers.pdf
Copyright License Agreement	11123-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	11123-Language certificate.pdf
Peer-review Report	11123-Peer review(s).pdf
Scientific Misconduct Check	11123-CrossCheck.jpg
Scientific Editor Work List	11123-Scientific editor work list.pdf