| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-1 signaling
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Emilien Loeuillard, Julien Bertrand, Anni Herranen, Chloé Melchior, Charlène Guérin, Moïse Coëffier, Moutaz Aziz, Pierre Déchelotte, Guillaume Savoye and Rachel Marion-Letellier |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Rachel Marion-Letellier, PhD, INSERM Unit UMR1073, Rouen University and Rouen University Hospital, 22, Boulevard Gambetta, Rouen Cedex 76183, France. marion_rachel@hotmail.com |
| Key Words |
Bortezomib; Colitis; Fibrosis; Proteasome |
| Core Tip |
Inflammatory bowel disease gives rise to challenging clinical conditions, and many patients have to undergo surgery throughout their life due to irreversible lesions. As no specific treatment is currently available for intestinal fibrosis, we tested an antifibrotic drug that is effective in other chronic inflammatory diseases. In the present study, we found that rats with 2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis exhibited colon fibrosis associated with high expression of transforming growth factor-? signaling, particularly in the Akt pathway. Nevertheless, we failed to inhibit colon fibrosis by proteasome inhibition in our experimental conditions. |
| Publish Date |
2015-01-06 09:08 |
| Citation |
Loeuillard E, Bertrand J, Herranen A, Melchior C, Guérin C, Coëffier M, Aziz M, Déchelotte P, Savoye G, Marion-Letellier R. 2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-b1 signaling. World J Gastroenterol 2014; 20(48): 18207-18215 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i48/18207.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i48.18207 |
