BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
12/22/2025 7:43:01 AM | Browse: 4 | Download: 38
Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 111245
Country India
Received
2025-06-26 04:16
Peer-Review Started
2025-06-26 04:17
First Decision by Editorial Office Director
2025-07-01 09:48
Return for Revision
2025-07-03 17:51
Revised
2025-07-28 02:42
Publication Fee Transferred
Second Decision by Editor
2025-10-27 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-10-27 09:55
Articles in Press
2025-10-27 09:55
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-12-15 03:45
Publish the Manuscript Online
2025-12-22 07:43
ISSN 2150-5330 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Guardians within: Cross-talk between the gut microbiome and host immune system
Manuscript Source Invited Manuscript
All Author List Nabanita Ghosh and Krishnendu Sinha
ORCID
Author(s) ORCID Number
Nabanita Ghosh http://orcid.org/0000-0003-1418-0017
Krishnendu Sinha http://orcid.org/0000-0001-9590-3875
Funding Agency and Grant Number
Corresponding Author Nabanita Ghosh, PhD, Department of Zoology, Maulana Azad College, No. 8 Rafi Ahmed Kidwai Road, Kolkata 700013, India. nabanitaghosh89@gmail.com
Key Words Gut microbiome; Immune system; Microbiota-immune axis; Dysbiosis; Inflammation
Core Tip This review highlights the critical interplay between the gut microbiome and the host immune system, focusing on how gut microbes and their metabolites, such as short-chain fatty acids, influence immune cell development, inflammatory regulation, and immune homeostasis. It emphasizes recent advances in metagenomics, metabolomics, and single-cell sequencing that have uncovered novel mechanisms of microbiota-driven immune modulation. The discussion also addresses the microbiome’s role in early-life immune education and its implications for autoimmune diseases, inflammation, and cancer immunotherapy, offering insights into emerging microbiome-based therapeutic strategies.
Publish Date 2025-12-22 07:43
Citation

Ghosh N, Sinha K. Guardians within: Cross-talk between the gut microbiome and host immune system. World J Gastrointest Pathophysiol 2025; 16(4): 111245

URL https://www.wjgnet.com/2150-5330/full/v16/i4/111245.htm
DOI https://dx.doi.org/10.4291/wjgp.v16.i4.111245
Full Article (PDF) WJGP-16-111245-with-cover.pdf
Manuscript File 111245_Auto_Edited_022345.docx
Answering Reviewers 111245-answering-reviewers.pdf
Audio Core Tip 111245-audio.mp3
Conflict-of-Interest Disclosure Form 111245-conflict-of-interest-statement.pdf
Copyright License Agreement 111245-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 111245-non-native-speakers.pdf
Peer-review Report 111245-peer-reviews.pdf
Scientific Misconduct Check 111245-scientific-misconduct-check.png
Scientific Editor Work List 111245-scientific-editor-work-list.pdf
CrossCheck Report 111245-crosscheck-report.pdf