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Articles Published Processes
12/5/2025 11:28:00 AM | Browse: 4 | Download: 11
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Received |
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2025-06-26 04:09 |
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Peer-Review Started |
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2025-06-26 04:09 |
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First Decision by Editorial Office Director |
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2025-07-16 08:55 |
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Return for Revision |
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2025-07-16 09:54 |
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Revised |
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2025-07-18 01:49 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-09-01 02:47 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-01 05:41 |
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Articles in Press |
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2025-09-01 05:41 |
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Edit the Manuscript by Language Editor |
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2025-09-02 07:20 |
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Typeset the Manuscript |
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2025-09-11 05:46 |
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Publish the Manuscript Online |
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2025-12-05 11:28 |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Neuromodulation involving vagus nerve mechanism: A promising method for treating gastrointestinal dysmotility
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jie Liu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jie Liu, PhD, Department of Gastroenterology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, No. 17 Lujiang Road, Hefei 230001, Anhui Province, China. feixilj@163.com |
| Key Words |
Electroacupuncture; Gastroparesis; Vagus nerve; Gastric motility; Neuromodulation |
| Core Tip |
The study by Zhang et al offers compelling mechanistic insights into how electroacupuncture at the stomach 36 (Zusanli) acupuncture point improves gastric dysmotility in diabetic gastroparesis via the nucleus tractus solitarius-vagal axis. This work significantly advances the understanding of acupuncture’s neuromodulatory effects, providing a scientific foundation for non-pharmacological management of diabetic gastroparesis. The authors identified a peripheral-to-central pathway: Electroacupuncture at the stomach 36 activated cholinergic targets, specifically choline acetyltransferase and the alpha 7 nicotinic acetylcholine receptor. This activation initiated signal transmission through spinal afferents in the L4 to L6 segments of the spinal cord, which were then integrated within the nucleus tractus solitarius, resulting in vagal efferent modulation of gastric targets. |
| Publish Date |
2025-12-05 11:28 |
| Citation |
Liu J. Neuromodulation involving vagus nerve mechanism: A promising method for treating gastrointestinal dysmotility. World J Gastrointest Pharmacol Ther 2025; 16(4): 111266 |
| URL |
https://www.wjgnet.com/2150-5349/full/v16/i4/111266.htm |
| DOI |
https://dx.doi.org/10.4292/wjgpt.v16.i4.111266 |
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