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Articles Published Processes
1/6/2015 9:08:00 AM | Browse: 1319 | Download: 1886
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Received |
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2014-05-06 08:54 |
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Peer-Review Started |
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2014-05-06 21:30 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-06-15 14:58 |
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Revised |
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2014-07-03 05:37 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-09-05 16:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-09-05 17:08 |
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Articles in Press |
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2014-09-05 17:24 |
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Edit the Manuscript by Language Editor |
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2014-11-26 23:27 |
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Typeset the Manuscript |
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2014-12-18 15:26 |
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Publish the Manuscript Online |
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2015-01-06 09:08 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hua Liu, Zhe Wang and Michael J Nowicki |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Institutional research grant by the University of Mississippi Medical Center |
68512250711 (to Dr. Hua Liu) |
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| Corresponding Author |
Hua Liu, MD, Division of Gastroenterology, Department of Pediatrics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, United States. hliu@umc.edu |
| Key Words |
Apoptosis; Carbon tetrachloride; Caspases; Endoplasmic reticulum; Hepatocyte; Reactive oxygen species |
| Core Tip |
Sublethal doses of carbon tetrachloride (CCl4) induced significant hepatocyte apoptosis and acute liver injury in the wild-type mice. CCl4 also induced the generation of reactive oxygen species in the liver followed by activation of caspase-12, -9 and -3. Loss of caspase-12 in knock-out mice attenuated CCl4-induced activation of caspase-9 and -3, significantly reduced apoptosis, and preserved liver function. Caspase-8 was not detected, indicating that it does not play a significant role in this model of hepatocyte apoptosis. The data indicate that caspase-12 plays a pivotal role in CCl4-induced hepatocyte apoptosis through the downstream activation of the effector caspase-3 directly and/or indirectly via caspase-9 activation. |
| Publish Date |
2015-01-06 09:08 |
| Citation |
Liu H, Wang Z, Nowicki MJ. Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice. World J Gastroenterol 2014; 20(48): 18189-18198 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i48/18189.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i48.18189 |
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