Publication Name	World Journal of Gastroenterology
Manuscript ID	11127
Country	United States

Received	2014-05-06 08:54
Peer-Review Started	2014-05-06 21:30
To Make the First Decision	2014-06-10 13:27
Return for Revision	2014-06-15 14:58
Revised	2014-07-03 05:37
Second Decision	2014-09-05 16:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-05 17:08
Articles in Press	2014-09-05 17:24
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-11-26 23:27
Typeset the Manuscript	2014-12-18 15:26
Publish the Manuscript Online	2015-01-06 09:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice
Manuscript Source	Unsolicited Manuscript
All Author List	Hua Liu, Zhe Wang and Michael J Nowicki
Funding Agency and Grant Number	Funding Agency Grant Number Institutional research grant by the University of Mississippi Medical Center 68512250711 (to Dr. Hua Liu)
Corresponding Author	Hua Liu, MD, Division of Gastroenterology, Department of Pediatrics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, United States. hliu@umc.edu
Key Words	Apoptosis; Carbon tetrachloride; Caspases; Endoplasmic reticulum; Hepatocyte; Reactive oxygen species
Core Tip	Sublethal doses of carbon tetrachloride (CCl4) induced significant hepatocyte apoptosis and acute liver injury in the wild-type mice. CCl4 also induced the generation of reactive oxygen species in the liver followed by activation of caspase-12, -9 and -3. Loss of caspase-12 in knock-out mice attenuated CCl4-induced activation of caspase-9 and -3, significantly reduced apoptosis, and preserved liver function. Caspase-8 was not detected, indicating that it does not play a significant role in this model of hepatocyte apoptosis. The data indicate that caspase-12 plays a pivotal role in CCl4-induced hepatocyte apoptosis through the downstream activation of the effector caspase-3 directly and/or indirectly via caspase-9 activation.
Publish Date	2015-01-06 09:08
Citation	Liu H, Wang Z, Nowicki MJ. Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice. World J Gastroenterol 2014; 20(48): 18189-18198
URL	http://www.wjgnet.com/1007-9327/full/v20/i48/18189.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i48.18189

Full Article (PDF)	WJG-20-18189.pdf
Full Article (Word)	WJG-20-18189.doc
Manuscript File	11127-Review.docx
Answering Reviewers	11127-Answering reviewers.pdf
Copyright License Agreement	11127-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140506021512.pdf
Peer-review Report	11127-Peer reviews.pdf
Scientific Misconduct Check	11127-CrossCheck.jpg
Scientific Editor Work List	11127-Scientific editor work list.pdf