Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	11128
Country	United Kingdom

Received	2014-05-06 08:52
Peer-Review Started	2014-05-06 19:47
To Make the First Decision	2014-07-10 17:25
Return for Revision	2014-07-11 14:18
Revised	2014-08-07 15:04
Second Decision	2014-09-10 09:04
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-10 09:26
Articles in Press	2014-09-10 09:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-10-31 10:36
Publish the Manuscript Online	2014-11-19 10:25

ISSN	2150-5330 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Pathophysiological mechanisms linking obesity and esophageal adenocarcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Leo Alexandre, Elizabeth Long and Ian LP Beales
Funding Agency and Grant Number
Corresponding Author	Dr. Ian LP Beales, MD, FRCP, Clinical Senior Lecturer and Honorary Consultant Gastroenterologist, Department of Gastroenterology, Norfolk and Norwich University Hospital, Colney Lane, Norwich, Norfolk NR4 7TJ, United Kingdom. i.beales@uea.ac.uk
Key Words	Adipose; Body mass index; Reflux; Barrett’s esophagus
Core Tip	Excess adipose tissue, particularly visceral obesity, is an important risk factor for esophageal adenocarcinoma (EAC). The mechanisms involve both the promotion of gastro-esophageal reflux and reflux-independent mechanisms. Abnormal secretion of the adipokines leptin and adiponectin from adipose tissue in obesity may promote the development of EAC. Increased leptin levels are an independent risk factor for EAC and leptin enhances proliferation and invasion and inhibits apoptosis in Barrett’s cell lines. Relative adiponectin deficiency is an independent risk factor for EAC and adiponectin blocks the cancer promoting effects of leptin in experimental models. Obesity may influence EAC development via adipokine secretion.
Publish Date	2014-11-19 10:25
Citation	Alexandre L, Long E, Beales ILP. Pathophysiological mechanisms linking obesity and esophageal adenocarcinoma. World J Gastrointest Pathophysiol 2014; 5(4): 534-549
URL	http://www.wjgnet.com/2150-5330/full/v5/i4/534.htm
DOI	http://dx.doi.org/10.4291/wjgp.v5.i4.534

Full Article (PDF)	WJGP-5-534.pdf
Full Article (Word)	WJGP-5-534.doc
Manuscript File	11128-Review.docx
Answering Reviewers	11128-Answering reviewers.pdf
Copyright License Agreement	11128-Copyright assignment.pdf
Peer-review Report	11128-Peer review(s).pdf
Scientific Misconduct Check	11128-CrossCheck.jpg
Scientific Editor Work List	11128-Scientific editor work list.pdf