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Articles Published Processes
1/20/2026 9:06:33 AM | Browse: 2 | Download: 0
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Received |
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2025-06-27 01:31 |
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Peer-Review Started |
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2025-06-27 01:32 |
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First Decision by Editorial Office Director |
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2025-07-15 09:55 |
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Return for Revision |
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2025-07-15 09:55 |
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Revised |
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2025-08-14 08:54 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-20 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-20 05:54 |
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Articles in Press |
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2025-11-20 05:54 |
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Edit the Manuscript by Language Editor |
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2025-11-30 01:12 |
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Typeset the Manuscript |
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2026-01-08 05:05 |
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Publish the Manuscript Online |
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2026-01-20 09:06 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Role of nanotechnology in modulating the tumor microenvironment to enhance immunotherapy efficacy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ayushi Jain, Saloni Verma, Alisha Jadhav, Sharon John and Shalini Gupta |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Shalini Gupta, Full Professor, Head, PhD, Department of Oral Pathology and Microbiology, King George’s Medical University, Department of Oral and Maxillofacial Pathology, King George’s Medical University, Lucknow, UP 226003 India, Lucknow 226003, Uttar Pradesh, India. dr.shalni@gmail.com |
| Key Words |
Immunotherapy; Oral squamous cell carcinoma; Nanomedicine; Tumor microenvironment; Tumor associated macrophages; Hypoxia; Nanoparticles |
| Core Tip |
Oral squamous cell carcinoma (OSCC) exhibits a highly immunosuppressive tumor microenvironment (TME) that severely limits immunotherapy efficacy. This review highlights how nanotechnology offers transformative strategies to overcome key TME barriers. Specifically, engineered nanoparticles can reprogram tumor-associated macrophages, alleviate hypoxia via oxygen-generating carriers, disrupt cancer-associated fibroblasts and extracellular matrix, and deliver targeted therapies (e.g., human papillomavirus E6/E7 siRNA). OSCC-tailored approaches also counteract carcinogen-induced oxidative stress and microbiota-driven immunosuppression. These innovations enable precise TME remodeling to enhance immune cell infiltration and checkpoint inhibitor performance, representing a paradigm shift towards improving clinical outcomes in oral cancer immunotherapy. |
| Publish Date |
2026-01-20 09:06 |
| Citation |
Jain A, Verma S, Jadhav A, John S, Gupta S. Role of nanotechnology in modulating the tumor microenvironment to enhance immunotherapy efficacy. World J Clin Oncol 2026; 17(1): 111294 |
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i1/111294.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v17.i1.111294 |
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