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Articles Published Processes
12/27/2025 2:50:51 AM | Browse: 0 | Download: 0
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Received |
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2025-06-30 01:22 |
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Peer-Review Started |
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2025-06-30 01:22 |
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First Decision by Editorial Office Director |
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2025-08-06 11:42 |
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Return for Revision |
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2025-08-06 11:42 |
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Revised |
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2025-09-17 11:51 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-10 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-10 10:13 |
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Articles in Press |
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2025-11-10 10:13 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-16 01:34 |
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Publish the Manuscript Online |
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2025-12-27 02:50 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Molecular links between inflammatory bowel disease and Alzheimer’s disease through immune signaling and inflammatory pathways
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Siva Sundara Kumar Durairajan, Abhay Kumar Singh, Shahitha M Sulaiman, Supriti Patnaik, Senthilkumar Krishnamoorthi, Ashok Iyaswamy, Balachandar Vellingiri, Chuan-Bin Yang and Leonard L Williams |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Siva Sundara Kumar Durairajan, Associate Professor, PhD, Molecular Mycology and Neurodegenerative Disease Research Laboratory, Department of Microbiology, Central University of Tamil Nadu, Neelakudi, Tiruvarur 610005, India. d.sivasundarakumar@cutn.ac.in |
| Key Words |
Inflammatory bowel disease; Alzheimer’s disease; Amyloidogenesis; Inflammatory pathways; Immune signaling; Gut-brain axis; Therapeutics |
| Core Tip |
This review provides evidence regarding the molecular connections between inflammatory bowel disease (IBD) and Alzheimer’s disease (AD). This interaction is facilitated mainly through immune signaling and inflammatory processes through the gut-brain axis. In IBD, chronic inflammation of the gut facilitates systemic inflammation, which may breach the blood-brain barrier and trigger neuroinflammation, amyloid-β accumulation, and cognitive impairment. The common mechanisms are the activation of the NLRP3 inflammasome, cytokine signaling dysregulation, and mitochondrial dysfunction. By inhibiting IBD-related inflammation via drugs or by modulating the microbiota, an approach based on neuroprotection can slow the progression of AD. |
| Publish Date |
2025-12-27 02:50 |
| Citation |
Durairajan SSK, Singh AK, Sulaiman SM, Patnaik S, Krishnamoorthi S, Iyaswamy A, Vellingiri B, Yang CB, Williams LL. Molecular links between inflammatory bowel disease and Alzheimer’s disease through immune signaling and inflammatory pathways. World J Gastroenterol 2025; 31(48): 111301 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i48/111301.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i48.111301 |
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