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Articles Published Processes
12/22/2025 7:43:00 AM | Browse: 0 | Download: 0
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Received |
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2025-06-27 01:06 |
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Peer-Review Started |
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2025-06-27 01:06 |
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First Decision by Editorial Office Director |
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2025-07-16 08:38 |
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Return for Revision |
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2025-07-16 08:38 |
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Revised |
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2025-07-30 01:54 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-09-15 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-17 10:28 |
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Articles in Press |
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2025-09-17 10:28 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-08 07:01 |
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Publish the Manuscript Online |
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2025-12-22 07:43 |
| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Drug-induced liver injury from high-dose intravenous methylprednisolone: A rare but known adverse effect
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kevan English |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Kevan English, MD, Department of Internal Medicine, University of Nebraska Medical Center, 42nd and Emile, Omaha, NE 68198, United States. keenglish@unmc.edu |
| Key Words |
Methylprednisolone; Drug-induced liver injury; Corticosteroids; Hepatotoxicity; Transaminitis; Glucocorticoids; Multiple sclerosis; Inflammation |
| Core Tip |
Corticosteroids are widely used in the treatment of various diseases. In general, these medications are considered safe. However, several recent cases have reported severe liver injury with high-dose methylprednisolone (Methyl-PNL). This article reports a case of asymptomatic hepatitis from high-dose Methyl-PNL that resolved with medication discontinuation. This known adverse effect should not preclude providers from treating various clinical conditions with high-dose Methyl-PNL. However, it should not be surprising if acute hepatitis or severe liver injury occurs as an adverse reaction, especially with high doses. We call for more providers to be aware of this idiosyncratic and rare drug side effect. |
| Publish Date |
2025-12-22 07:43 |
| Citation |
English K. Drug-induced liver injury from high-dose intravenous methylprednisolone: A rare but known adverse effect. World J Gastrointest Pathophysiol 2025; 16(4): 111306 |
| URL |
https://www.wjgnet.com/2150-5330/full/v16/i4/111306.htm |
| DOI |
https://dx.doi.org/10.4291/wjgp.v16.i4.111306 |
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