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Articles Published Processes
1/20/2026 2:54:07 AM | Browse: 4 | Download: 4
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Received |
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2025-07-01 09:18 |
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Peer-Review Started |
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2025-07-01 09:18 |
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First Decision by Editorial Office Director |
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2025-07-24 08:05 |
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Return for Revision |
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2025-07-24 08:05 |
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Revised |
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2025-08-07 15:09 |
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Publication Fee Transferred |
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2025-08-15 01:09 |
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Second Decision by Editor |
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2025-11-18 01:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-18 02:04 |
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Articles in Press |
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2025-11-18 02:04 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-08 09:51 |
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Publish the Manuscript Online |
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2026-01-20 02:54 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Breast cancer stem cell activity driven by ME18D gene expression in the tumor microenvironment
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
De-Yang Guo, Zhang-Yi Liu and Qian-Chuan Yi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Yongchuan District |
2023yc-jckx20021 |
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| Corresponding Author |
Qian-Chuan Yi, Department of General Surgery, University-Town Hospital of Chongqing Medical University, No. 55 Daxuecheng Middle Road, Shapingba District, Chongqing 401331, China. anyway173@163.com |
| Key Words |
Breast cancer stem cells; Surface markers; Transcriptomics; Least absolute shrinkage and selection operator regression; Prognostic model |
| Core Tip |
This study integrates flow cytometry, transcriptomics, least absolute shrinkage and selection operator modeling, single-cell and spatial transcriptomics to comprehensively characterize breast cancer stem cells. CD105 was identified as a key surface marker, and a prognostic gene signature including MED18 was developed. MED18 showed strong correlations with tumor, immune, and stromal cells, suggesting a central role in breast cancer stem cell regulation and microenvironment interaction. These findings offer novel insights into tumor heterogeneity and provide potential biomarkers and therapeutic targets for precision treatment in breast cancer. |
| Publish Date |
2026-01-20 02:54 |
| Citation |
Guo DY, Liu ZY, Yi QC. Breast cancer stem cell activity driven by ME18D gene expression in the tumor microenvironment. World J Stem Cells 2026; 18(1): 111348 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i1/111348.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i1.111348 |
© 2004-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
