| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Sequential changes of antibiotic resistances of Helicobacter pylori in Taiwan from 2019 to 2024
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Pei-Jui Wu, Feng-Woei Tsay, Deng-Chyang Wu, Jyh-Chin Yang, Seng-Kee Chuah, Kuan-Yang Chen, Chien-Lin Chen, Chia-Long Lee, Chih-An Shih, Yu-Hwa Liu, Sz-Iuan Shiu, Wei-Chen Tai, Chao-Hung Kuo, Wei-Yi Lei, Sung-Shuo Kao, Tzung-Jiun Tsai, I-Che Feng, Mitsuhiro Koseki, Ping-I Hsu and Ming-Jen Sheu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| An Nan Hospital, China Medical University |
No. ANHRF114-20 |
| An Nan Hospital, China Medical University |
No. ANHRF114-21 |
|
| Corresponding Author |
Ping-I Hsu, MD, Professor, Division of Gastroenterology, Department of Internal Medicine, An Nan Hospital, China Medical University, No. 66, Sec. 2, Changhe Road, Tainan 709204, Taiwan. williamhsup@yahoo.com.tw |
| Key Words |
Helicobacter pylori; Resistance; Antibiotic; Amoxicillin; Clarithromycin; Metronidazole; Tetracycline; Levofloxacin |
| Core Tip |
Antibiotic resistance significantly impacts the treatment failure rates of Helicobacter pylori (H. pylori) infections. We analyzed the trends in single and dual resistance profiles of H. pylori treatment-naive Taiwanese between January 2019 and December 2024. Primary antibiotic resistance to tetracycline in H. pylori has increased in Taiwan from 2019 to 2024, while resistance to metronidazole have decreased during the same period. Additionally, the dual resistance to clarithromycin plus tetracycline and metronidazole plus tetracycline both increased significantly. These changes carry major clinical implications: It threatens the efficacy of bismuth-based quadruple therapy and limit the treatment options. |
| Publish Date |
2025-10-21 09:08 |
| Citation |
<p>Wu PJ, Tsay FW, Wu DC, Yang JC, Chuah SK, Chen KY, Chen CL, Lee CL, Shih CA, Liu YH, Shiu SI, Tai WC, Kuo CH, Lei WY, Kao SS, Tsai TJ, Feng IC, Koseki M, Hsu PI, Sheu MJ. Sequential changes of antibiotic resistances of Helicobacter pylori in Taiwan from 2019 to 2024. <i>World J Gastroenterol</i> 2025; 31(39): 111380</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i39/111380.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i39.111380 |
