| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Radiology, Nuclear Medicine & Medical Imaging |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Hepatic enhancement and signal intensity analysis on magnetic resonance imaging as prognostic biomarkers in advanced chronic liver disease
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Bogdan-Ioan Stanciu, Marcela Iojiban, Andreea Morariu-Barb, Cosmin Caraiani, Bogdan Procopet, Horia Stefanescu and Monica Lupsor-Platon |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Monica Lupsor-Platon, MD, PhD, Professor, Department of Radiology and Medical Imaging, “Iuliu Hațieganu” University of Medicine and Pharmacy, Str. Victor Babeş No. 8, Cluj-Napoca 400012, Cluj, Romania. monica.lupsor@umfcluj.ro |
| Key Words |
Advanced chronic liver disease; Magnetic resonance imaging; Gadoxetate disodium; Hepatic enhancement; Signal intensity; Prognostic biomarkers; Liver function assessment |
| Core Tip |
This study investigated whether quantitative gadoxetate-enhanced magnetic resonance imaging can enhance prognostic assessment in patients with advanced chronic liver disease. Among 100 patients, hepatic enhancement (HE) and signal intensity were measured segmentally and globally. Global HE correlated strongly with Functional Liver Imaging Score, clinico-biological scores (Child-Pugh, Model of End-stage Liver Disease 3.0, Albumin-Bilirubin, and Fibrosis-4), liver stiffness, and portal pressure. Notably, lower HE independently predicted hepatic decompensation and mortality, demonstrating good diagnostic accuracy. These results suggest that HE provides an objective and reproducible biomarker that may complement conventional scoring systems, facilitating the earlier identification of high-risk patients and supporting personalized management strategies in clinical hepatology. |
| Publish Date |
2025-12-26 10:27 |
| Citation |
Stanciu BI, Iojiban M, Morariu-Barb A, Caraiani C, Procopet B, Stefanescu H, Lupsor-Platon M. Hepatic enhancement and signal intensity analysis on magnetic resonance imaging as prognostic biomarkers in advanced chronic liver disease. World J Hepatol 2025; 17(12): 111418 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i12/111418.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i12.111418 |
