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Articles Published Processes
1/20/2026 9:06:33 AM | Browse: 47 | Download: 149
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Received |
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2025-07-07 07:51 |
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Peer-Review Started |
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2025-07-07 07:51 |
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First Decision by Editorial Office Director |
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2025-07-22 09:20 |
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Return for Revision |
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2025-07-22 09:20 |
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Revised |
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2025-07-29 00:02 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-11 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-11 12:19 |
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Articles in Press |
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2025-12-11 12:19 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-08 00:30 |
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Publish the Manuscript Online |
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2026-01-20 09:06 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Evaluating murine double minute 2 status as a stratification tool for risk-adapted management in plasma cell neoplasms
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Noura A A Ebrahim, Habiba Elfandy, Aya Mohamed Adel Arafat, Amira Diyaa Darwish and Mahitab Ibrahim Eltohamy |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Noura A A Ebrahim, Oncologic Pathology, National Cancer Institute, Cairo University, 1st Kasr Alainy street, Cairo 11796, Al Qāhirah, Egypt. npathologist@gmail.com |
| Key Words |
Multiple myeloma; Murine double minute 2; Plasma cell neoplasms; Immunohistochemistry; Prognostic biomarker; Relapse-free survival; p53 pathway; Risk stratification; CD45; Epithelial membrane antigen |
| Core Tip |
This research explores the prognostic significance of murine double minute 2 (MDM2) expression in plasma cell neoplasms, with particular attention to plasmacytomas. The findings reveal a distinct subset of patients with MDM2 positivity who demonstrate poorer early treatment responses and markedly shorter relapse-free survival intervals. Incorporating MDM2 expression into contemporary prognostic frameworks could enhance individualized treatment planning for those with multiple myeloma. Overall, the evidence indicates that MDM2 functions as both a marker of aggressive tumor biology and a promising indicator for early-stage risk stratification, supporting more vigilant follow-up and personalized therapeutic intervention to reduce relapse likelihood. |
| Publish Date |
2026-01-20 09:06 |
| Citation |
Ebrahim NAA, Elfandy H, Arafat AMA, Darwish AD, Eltohamy MI. Evaluating murine double minute 2 status as a stratification tool for risk-adapted management in plasma cell neoplasms. World J Clin Oncol 2026; 17(1): 111426 |
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i1/111426.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v17.i1.111426 |
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