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Articles Published Processes
10/24/2025 7:36:28 AM | Browse: 125 | Download: 72
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Received |
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2025-07-01 06:38 |
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Peer-Review Started |
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2025-07-01 06:38 |
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To Make the First Decision |
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Return for Revision |
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2025-07-18 07:22 |
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Revised |
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2025-08-01 00:37 |
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Second Decision |
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2025-08-25 03:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-25 09:28 |
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Articles in Press |
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2025-08-25 09:28 |
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Publication Fee Transferred |
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2025-08-03 09:14 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-13 00:22 |
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Publish the Manuscript Online |
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2025-10-24 07:36 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Reduction in the hepatocellular carcinoma antioncogene SLC39A14 during the malignant progression of hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei Guo, Ming-Xuan Wang, Tong Mu, Kan Xu, Zhao-Di Jiang, Xue-Hua Wan, Jun-Wei Li and Yong-Xiang Yi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Postgraduate Research & Practice Innovation Program of Jiangsu Province |
SJCX23-0857 |
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| Corresponding Author |
Yong-Xiang Yi, MD, PhD, Clinical Research Center, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, No. 1 Kangfu Road, Tangshan Subdistrict, Jiangning District, Nanjing 211113, Jiangsu Province, China. ian0126@126.com |
| Key Words |
Apoptosis; Epithelial–mesenchymal transition; Hepatocellular carcinoma |
| Core Tip |
This study's findings associate SLC39A14 downregulation with hepatocellular carcinoma (HCC) progression. SLC39A14 overexpression inhibits HCC cell proliferation, migration, and invasion while promoting apoptosis via the BCL-2/BAX/caspase-3 pathway. Bioinformatics analysis suggests that STAT3 regulates the expression of SLC39A14. Our findings together highlight SLC39A14-BCL-2/BAX/caspase-3 and SLC39A14-EMT axes as potential therapeutic targets for HCC. |
| Publish Date |
2025-10-24 07:36 |
| Citation |
<p>Guo W, Wang MX, Mu T, Xu K, Jiang ZD, Wan XH, Li JW, Yi YX. Reduction in the hepatocellular carcinoma antioncogene SLC39A14 during the malignant progression of hepatocellular carcinoma. <i>World J Gastrointest Surg</i> 2025; 17(10): 111454</p> |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i10/111454.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i10.111454 |
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