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Articles Published Processes
4/3/2026 6:41:51 AM | Browse: 2 | Download: 0
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Received |
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2025-07-01 09:47 |
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Peer-Review Started |
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2025-07-01 09:48 |
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First Decision by Editorial Office Director |
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2025-07-29 09:48 |
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Return for Revision |
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2025-07-29 09:48 |
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Revised |
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2025-09-12 14:45 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-04 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-04 10:02 |
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Articles in Press |
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2026-02-04 10:02 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-27 02:26 |
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Publish the Manuscript Online |
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2026-04-03 06:41 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Optimal cannabinoid-terpene combination ratios suppress mutagenicity of gastric reflux in normal and metaplastic esophageal cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Aaron Goldman, Gabriel Gonzalez, Svetlana A Karpova, Leutz Buon, Masood A Shammas, Hiroshi Mashimo, Markus H Frank and Natasha Y Frank |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health |
No. R01EY025794 |
| National Institutes of Health |
No. R01HL161087 |
| National Institutes of Health |
No. P01AG071463 |
| National Institutes of Health |
No. 1K01CA226375-01A1 |
| Veterans Administration Research and Development Merit Review Awards |
No. 1I01BX000516 |
| Veterans Administration Research and Development Merit Review Awards |
No. 1I01RX000989 |
| Veterans Administration Research and Development Merit Review Awards |
No. 1I01BX006004 |
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| Corresponding Author |
Natasha Y Frank, Department of Medicine, VA Boston Healthcare, 1400 VFW Parkway, Building 3, Suite 2A105, Boston, MA 02132, United States. nyfrank@bwh.harvard.edu |
| Key Words |
Gastroesophageal reflux disease; Bile acids; DNA damage; New therapeutics; Cannabinoids; Reactive oxygen species; DNA repair |
| Core Tip |
Activation of the endocannabinoid system (ECS) with specific cannabinoid-terpene combinations and ratios has been shown to protect esophageal cells from bile acid-induced DNA damage and mutations, which are key drivers of esophageal adenocarcinoma (EAC). In vitro models revealed that a 1:5 ratio of cannabigerol to phytol or β-caryophyllene significantly reduced DNA damage and oxidative stress while preserving mitochondrial function. This combination also promoted apoptosis in damaged cells, while the ECS receptor expression patterns correlated with EAC progression. These findings indicate that ECS modulation may represent a novel therapeutic strategy for EAC and related conditions. |
| Publish Date |
2026-04-03 06:41 |
| Citation |
Goldman A, Gonzalez G, Karpova SA, Buon L, Shammas MA, Mashimo H, Frank MH, Frank NY. Optimal cannabinoid-terpene combination ratios suppress mutagenicity of gastric reflux in normal and metaplastic esophageal cells. World J Gastroenterol 2026; 32(14): 111455 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i14/111455.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i14.111455 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
