| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Hypothalamic-pituitary-adrenal dysregulation and psychological distress in Crohn’s disease: Insights from acute and chronic stress responses
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Effrosini Laoudi, Demetra Papalouka, Georgios Kokkotis, Michael Gkizis, Aimilia Mantzou, Georgios Lyrakos, Panagiotis Markopoulos, Paraskevi Prapa, Theodoros Voulgaris, John Vlachogiannakos, Ioannis Papaconstantinou and Giorgos Bamias |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Panagiotis Markopoulos, Consultant, MD, PhD, Department of Gastroenterology, Metaxa Cancer Hospital, 51 Mpotasi Street, Piraeus 18537, Greece. panosmarkmd@gmail.com |
| Key Words |
Crohn’s disease; Chronic stress; Acute stress; Hypothalamic-pituitary-adrenal axis dysregulation; Hair cortisol; Salivary cortisol |
| Core Tip |
In this prospective study, we evaluated both acute and chronic stress responses in patients with Crohn’s disease using objective biomarkers - salivary and hair cortisol - in two distinct patient groups. In addition, we assessed perceived psychological stress via validated psychometric tools and compared these findings with those of a control group of patients with cancer. Our findings reveal a significantly decreased cortisol response to chronic stress in patients with Crohn’s disease, along with high levels of perceived stress, anxiety, and depression. |
| Publish Date |
2026-02-28 08:32 |
| Citation |
Laoudi E, Papalouka D, Kokkotis G, Gkizis M, Mantzou A, Lyrakos G, Markopoulos P, Prapa P, Voulgaris T, Vlachogiannakos J, Papaconstantinou I, Bamias G. Hypothalamic-pituitary-adrenal dysregulation and psychological distress in Crohn’s disease: Insights from acute and chronic stress responses. World J Psychiatry 2026; 16(3): 111523 |
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i3/111523.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i3.111523 |
