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1/14/2026 8:39:32 AM | Browse: 0 | Download: 0
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Received |
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2025-07-02 01:48 |
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Peer-Review Started |
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2025-07-02 01:48 |
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First Decision by Editorial Office Director |
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2025-08-14 08:38 |
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Return for Revision |
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2025-08-14 08:38 |
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Revised |
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2025-08-23 16:42 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-01 02:57 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-01 10:53 |
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Articles in Press |
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2025-12-01 10:53 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-07 07:22 |
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Publish the Manuscript Online |
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2026-01-14 08:39 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Review |
| Article Title |
Update on diagnostic and therapeutic strategies for antibody-mediated rejection in kidney transplantation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tabassum Elahi, Saima Ahmed and Muhammed Mubarak |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Muhammed Mubarak, Department of Histopathology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sindh, Pakistan. drmubaraksiut@yahoo.com |
| Key Words |
Antibodies; Kidney; Transplantation; Rejection; Diagnosis |
| Core Tip |
Antibody-mediated rejection remains a leading cause of kidney graft dysfunction and failure. While donor-specific antibodies are a key risk factor, not all are pathogenic. Current diagnostic markers lack sensitivity and often miss subclinical changes, with definitive diagnosis still relying on invasive biopsy. The clinical adoption of noninvasive biomarkers continues to face significant hurdles. Despite advances in understanding antibody-mediated rejection biology, no standardized or approved treatment currently exists. Present guidelines are largely based on earlier consensus, although emerging therapies such as CD38 antibodies and complement inhibitors show promise, particularly in early or severe cases. |
| Publish Date |
2026-01-14 08:39 |
| Citation |
Elahi T, Ahmed S, Mubarak M. Update on diagnostic and therapeutic strategies for antibody-mediated rejection in kidney transplantation. World J Transplant 2026; 16(1): 111524 |
| URL |
https://www.wjgnet.com/2220-3230/full/v16/i1/111524.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v16.i1.111524 |
© 2004-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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