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10/15/2025 9:03:20 AM | Browse: 27 | Download: 131
Publication Name World Journal of Diabetes
Manuscript ID 111548
Country China
Received
2025-07-03 03:57
Peer-Review Started
2025-07-07 09:17
First Decision by Editorial Office Director
2025-07-18 07:26
Return for Revision
2025-07-18 07:26
Revised
2025-07-29 15:08
Publication Fee Transferred
2025-08-02 08:57
Second Decision by Editor
2025-08-21 08:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-09-02 08:17
Articles in Press
2025-09-02 08:17
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-10-09 15:11
Publish the Manuscript Online
2025-10-15 09:03
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Retrospective Study
Article Title Serum alpha-1-microglobulin as a predictor of multiple complications in type 2 diabetes mellitus patients
Manuscript Source Unsolicited Manuscript
All Author List Li-Chao Ge, Yu-Ling Zhang, Gui-Liang Peng, Min Long, Tao Jin, Bin Lu, Jia-Qing Shao and Xing Li
ORCID
Author(s) ORCID Number
Jia-Qing Shao http://orcid.org/0000-0002-9739-5410
Xing Li http://orcid.org/0000-0001-6469-4839
Funding Agency and Grant Number
Corresponding Author Xing Li, PhD, Professor, Department of Endocrinology, Jinling Clinical Medical College, Nanjing Medical University, No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China. xiahcaihong@163.com
Key Words Alpha-1-microglobulin; Microvascular complications; Cardiac complications; Type 2 diabetes mellitus; Machine learning models
Core Tip Research on the relationship between serum alpha-1-microglobulin (α1-MG) and multiple complications in patients with type 2 diabetes mellitus (T2DM) is limited. Our study revealed a significant correlation between elevated α1-MG levels and the risk of diabetic nephropathy, diabetic retinopathy, diabetic peripheral neuropathy, and left ventricular hypertrophy. By combining traditional statistics with machine learning, we established the diagnostic value of α1-MG for microvascular and cardiac complications, demonstrating its superior performance in early risk prediction. These findings indicate the potential of α1-MG as a biomarker for predicting multiple complications in patients with T2DM.
Publish Date 2025-10-15 09:03
Citation

Ge LC, Zhang YL, Peng GL, Long M, Jin T, Lu B, Shao JQ, Li X. Serum alpha-1-microglobulin as a predictor of multiple complications in type 2 diabetes mellitus patients. World J Diabetes 2025; 16(10): 111548

URL https://www.wjgnet.com/1948-9358/full/v16/i10/111548.htm
DOI https://dx.doi.org/10.4239/wjd.v16.i10.111548
Full Article (PDF) WJD-16-111548-with-cover.pdf
Manuscript File 111548_Auto_Edited_084951.docx
Answering Reviewers 111548-answering-reviewers.pdf
Audio Core Tip 111548-audio.wav
Biostatistics Review Certificate 111548-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 111548-conflict-of-interest-statement.pdf
Copyright License Agreement 111548-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 111548-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 111548-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 111548-non-native-speakers.pdf
Supplementary Material 111548-supplementary-material.pdf
Peer-review Report 111548-peer-reviews.pdf
Journal Editor-in-Chief Review Report 111548-journal-editor-in-chief.pdf
Scientific Misconduct Check 111548-scientific-misconduct-check.png
Scientific Editor Work List 111548-scientific-editor-work-list.pdf
CrossCheck Report 111548-crosscheck-report.pdf