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Articles Published Processes
9/19/2025 7:57:21 AM | Browse: 337 | Download: 123
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Received |
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2025-07-03 13:38 |
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Peer-Review Started |
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2025-07-03 13:38 |
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To Make the First Decision |
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Return for Revision |
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2025-07-28 09:02 |
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Revised |
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2025-08-06 13:51 |
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Second Decision |
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2025-08-25 03:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-25 07:31 |
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Articles in Press |
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2025-08-25 07:31 |
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Publication Fee Transferred |
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2025-08-07 12:37 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-11 06:47 |
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Publish the Manuscript Online |
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2025-09-19 07:57 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Peroxiredoxin 1 inhibits tumorigenesis by activating the NLRP3/GSDMD pathway to induce pyroptosis of colorectal cancer cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ying He, Jing Liu, Ning Zhou, Ling-Xiang Xie, Yong-Fang Jiang and Chun-Lan Chen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82302454 |
| Natural Science Foundation of Hunan Province |
2025JJ60797 |
| Natural Science Foundation of Hunan Province |
2025JJ60734 |
| Natural Science Foundation of Hunan Province |
2022JJ40718 |
| Guangdong Basic and Applied Basic Research Foundation |
2022A1515111063 |
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| Corresponding Author |
Chun-Lan Chen, PhD, Department of Pulmonary and Critical Care Medicine, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, No. 61 Jiefang Road, Furong District, Changsha 410005, Hunan Province, China. cclen208@163.com |
| Key Words |
Colorectal cancer; Peroxiredoxin 1; Damage associated molecular patterns; Pyroptosis; Gasdermin D |
| Core Tip |
Peroxiredoxin 1 (Prdx1) as a damage associated molecular pattern could inhibit the viability, proliferation, migration and invasion of RKO and SW480 cells; mechanistically, Prdx1 activates NLRP3 inflammasome/gasdermin D (GSDMD) pathway to induce pyroptosis of colorectal cancer cells. In conclusion, our findings demonstrated that Prdx1 induces pyroptosis by activating NLRP3 inflammasome/GSDMD pathway, thereby inhibiting the malignant biological behavior of RKO and SW480 colon cancer cells. |
| Publish Date |
2025-09-19 07:57 |
| Citation |
<p>He Y, Liu J, Zhou N, Xie LX, Jiang YF, Chen CL. Peroxiredoxin 1 inhibits tumorigenesis by activating the NLRP3/GSDMD pathway to induce pyroptosis of colorectal cancer cells. <i>World J Gastroenterol</i> 2025; 31(36): 111557</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i36/111557.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i36.111557 |
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