| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Genetic predeterminants and recent advancements in steatotic liver disease: A roadmap toward precision hepatology
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ganesh Kumar, Yash R Shah, Abeer Shahzad, Khadija Jameel, David Guevara-Lazo, Najia Ali Khan, Dushyant Singh Dahiya, Manesh Kumar Gangwani, Rakshana Ravichandran, Ravi Patel, Umar Hayat and Ragesh B Thandassery |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Yash R Shah, MD, Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205, United States. yashu211996@gmail.com |
| Key Words |
Steatotic liver disease; PNPLA3; TM6SF2; GCKR; MBOAT7; HSD17B14; Metabolic dysfunction-associated steatotic liver disease; Hepatocellular carcinoma |
| Core Tip |
Steatotic liver disease is a chronic disorder, characterized by the excessive accumulation of fat in the liver. It is the most common cause of cirrhosis and hepatocellular carcinoma. Many genetic factors including PNPLA3, TM6SF2, GCKR, MBOAT7, HSD17B14 etc. contribute to the development of the disease apart from the various metabolic and endocrine etiologies. Deciphering these genetic markers will help not only in the understanding of pathogenesis but can lead to the development of the various targeted therapies and diagnostic modalities. In this article, we review the genetic markers associated with the steatotic liver disease, their ethnic distribution and implication in the therapeutic and diagnostic advancements. |
| Publish Date |
2025-11-27 07:53 |
| Citation |
Kumar G, Shah YR, Shahzad A, Jameel K, Guevara-Lazo D, Khan NA, Dahiya DS, Gangwani MK, Ravichandran R, Patel R, Hayat U, Thandassery RB. Genetic predeterminants and recent advancements in steatotic liver disease: A roadmap toward precision hepatology. World J Hepatol 2025; 17(11): 111576 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i11/111576.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i11.111576 |
