| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Systematic pan-cancer analysis reveals the prognostic and immunological roles of ectonucleoside triphosphate diphosphohydrolase 6
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Gang Wang, Tao Liu, Jia-Xing Zhang, Yi-Rong Li, Wei-Jing Zhu, Jing-Lan Wang, Wei-Wei Dong, Yu-Yu Zhang, Yu-Min Li, Lu-Xi Yang, Li-Xia He and Wen-Ting He |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Science and Technology Program of Gansu Province |
23JRRA1015 |
| the International Science and Technology Cooperation Project of Gansu Provincial Science and Technology Department |
2023YFWA0009 |
| the Innovation and Entrepreneurship Project for Young Talents of Lanzhou Science and Technology Bureau |
2023-4-18 |
|
| Corresponding Author |
Wen-Ting He, The Second Hospital & Clinical Medical School, Lanzhou University, No. 82 Cuiyingmen, Chengguan District, Lanzhou 730030, Gansu Province, China. hewt@lzu.edu.cn |
| Key Words |
Ectonucleoside triphosphate diphosphohydrolase 6; Pan-cancer analysis; Immunotherapy; Biomarker; Molecular docking |
| Core Tip |
Ectonucleoside triphosphate diphosphohydrolase 6 (ENTPD6), a member of the ENTPD family, was highly expressed in kidney renal clear cell carcinoma, liver hepatocellular carcinoma, kidney renal papillary cell carcinoma, endocervical adenocarcinoma, and other malignancies, indicating it could be a potential biomarker. In this study, we performed a comprehensive analysis examining the correlation between ENTPD6 expression and various factors, including prognosis, genetic alterations, epigenetic modification, immune infiltration, immunotherapy responses, functional enrichment, and drug sensitivity. Our findings yield novel insights into the role of ENTPD6 in cancer biology and bolster global research on its potential as a therapeutic target. |
| Publish Date |
2025-11-21 07:06 |
| Citation |
<p>Wang G, Liu T, Zhang JX, Li YR, Zhu WJ, Wang JL, Dong WW, Zhang YY, Li YM, Yang LX, He LX, He WT. Systematic pan-cancer analysis reveals the prognostic and immunological roles of ectonucleoside triphosphate diphosphohydrolase 6. <i>World J Clin Oncol</i> 2025; 16(11): 111627</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i11/111627.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i11.111627 |
