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Articles Published Processes
10/24/2025 7:36:30 AM | Browse: 5 | Download: 0
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Received |
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2025-07-06 13:07 |
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Peer-Review Started |
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2025-07-06 13:08 |
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To Make the First Decision |
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Return for Revision |
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2025-07-15 12:42 |
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Revised |
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2025-07-20 14:50 |
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Second Decision |
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2025-09-02 02:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-02 03:45 |
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Articles in Press |
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2025-09-02 03:45 |
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Publication Fee Transferred |
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2025-07-24 10:05 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-10 07:00 |
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Publish the Manuscript Online |
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2025-10-24 07:36 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Review |
| Article Title |
Intestinal reengineering: Scientific advances in intestinal transplantation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yao Rong, Chen-Yang Nie, Ji-Dian Zhou, Zi-Cheng Wang, Di-Lin Wu, Sheng-Wei Wu and Zheng-Yong Xie |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangdong Provincial Medical Research Fund General Program |
B2025209 |
| Guangzhou Science and Technology Program Project |
2025A03J3269 |
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| Corresponding Author |
Zheng-Yong Xie, Chief Physician, Professor, Department of General Surgery, The General Hospital of Southern Theater Command, No. 111 Liuhua Road, Yuexiu District, Guangzhou 510000, Guangdong Province, China. zhengyongx2020@126.com |
| Key Words |
Intestinal transplantation; Immune rejection; Intestinal flora; Immunosuppression; Intestinal autotransplantation |
| Core Tip |
This review systematically elucidates the current status and challenges of intestinal transplantation (ITx) as a life-saving therapy for patients with irreversible intestinal failure. Despite therapeutic hurdles such as the high immunogenicity of the intestine, complex microbiota microenvironment, and susceptibility to rejection, surgical innovations-including robot-assisted vascular anastomosis and multivisceral transplantation-along with breakthroughs in ex vivo perfusion technology have significantly improved clinical outcomes. This review highlights that bidirectional immune reactions (host-versus-graft response and graft-versus-host disease) and chronic rejection remain the primary clinical obstacles. Analysis herein reveals marked differences in immunological profiles and clinical manifestations between pediatric and adult recipients, necessitating individualized treatment strategies. Based on current research advances, future directions include precision immunotherapy, gut microbiota modulation, and bioengineering innovations such as 3D bioprinted grafts. The review emphasizes that only through multidisciplinary collaboration can ITx evolve into a safer and more effective treatment, ultimately achieving comprehensive improvements in long-term survival rates and quality of life for patients. |
| Publish Date |
2025-10-24 07:36 |
| Citation |
<p>Rong Y, Nie CY, Zhou JD, Wang ZC, Wu DL, Wu SW, Xie ZY. Intestinal reengineering: Scientific advances in intestinal transplantation. <i>World J Gastrointest Surg</i> 2025; 17(10): 111672</p> |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i10/111672.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i10.111672 |
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