| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Randomized Clinical Trial |
| Article Title |
Impact of achieving glycated hemoglobin targets on cardiovascular events/mortality: Post-hoc analysis of the nephropathy in diabetes type 2 trial
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Alfredo Caturano, Vittorio Simeon, Raffaele Galiero, Vincenzo Russo, Luca De Nicola, Paolo Chiodini, Luca Rinaldi, Erica Vetrano, Teresa Salvatore, Caterina Conte, Carlo Acierno, Celestino Sardu, Raffaele Marfella, Roberto Minutolo and Ferdinando C Sasso |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministero dell’ Università e della Ricerca (Italian Ministry of University and Research) |
No. 2007PSYLRX |
|
| Corresponding Author |
Caterina Conte, Professor, Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma University, Via di val Cannuta, 247, Rome 00166, Italy. caterina.conte@uniroma5.it |
| Key Words |
Type 2 diabetes mellitus; Glycated hemoglobin; Multifactorial intervention; Cardiovascular diseases; Risk factors; Diabetic complications |
| Core Tip |
In high-risk patients with type 2 diabetes, achieving a glycated hemoglobin ≤ 7% was associated with fewer cardiovascular events only under standard care conditions, suggesting that the cardiovascular benefit of glycemic control may depend on treatment intensity. In contrast, younger age, female sex, and blood pressure control were more consistent predictors of improved outcomes. Low-density lipoprotein cholesterol control showed a borderline association with reduced mortality in the standard of care group only. |
| Publish Date |
2025-11-14 08:23 |
| Citation |
<p>Caturano A, Simeon V, Galiero R, Russo V, De Nicola L, Chiodini P, Rinaldi L, Vetrano E, Salvatore T, Conte C, Acierno C, Sardu C, Marfella R, Minutolo R, Sasso FC. Impact of achieving glycated hemoglobin targets on cardiovascular events/mortality: Post-hoc analysis of the nephropathy in diabetes type 2 trial. <i>World J Diabetes</i> 2025; 16(11): 111698</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i11/111698.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i11.111698 |
