| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Insights into the GALAD score: A new optimal cut-off for hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Erica Villa, Rossella Donghia, Sergio Coletta, Caterina Bonfiglio, Rosina Maria Critelli, Anna Ancona, Endrit Shahini, Palma Aurelia Iacovazzi, Raffaele Cozzolongo, Francesca Pavone, Nicola Carella, Patrizia Pontisso, Andrea Martini, Sherin Al Aoua, Heike Bantel and Gianluigi Giannelli |
| ORCID |
|
| Funding Agency and Grant Number |
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| Corresponding Author |
Gianluigi Giannelli, Director, Professor, Scientific Direction, National Institute of Gastroenterology-IRCCS “Saverio de Bellis”, Via Turi, 27, Castellana Grotte 70013, Puglia, Italy. gianluigi.giannelli@irccsdebellis.it |
| Key Words |
Chronic liver disease; Hepatocellular carcinoma; Cirrhosis; Early detection; GALAD |
| Core Tip |
The GALAD score, combining gender, age, alpha-fetoprotein (AFP), AFP-L3, and des-gamma-carboxy prothrombin levels, is a promising tool for identifying hepatocellular carcinoma (HCC). In this multi-center study involving 1431 subjects, we propose a cut-off of -1.67 to distinguish HCC from healthy individuals, and -0.77 to differentiate HCC from cirrhotic patients, achieving high sensitivity and specificity. These thresholds can enhance early HCC detection and are recommended for integration into screening protocols. Future studies should validate these findings, particularly in metabolic-associated steatotic liver disease-related liver disease, which is becoming increasingly prevalent worldwide. |
| Publish Date |
2025-10-27 08:08 |
| Citation |
<p>Villa E, Donghia R, Coletta S, Bonfiglio C, Critelli RM, Ancona A, Shahini E, Iacovazzi PA, Cozzolongo R, Pavone F, Carella N, Pontisso P, Martini A, Al Aoua S, Bantel H, Giannelli G. Insights into the GALAD score: A new optimal cut-off for hepatocellular carcinoma. <i>World J Gastroenterol</i> 2025; 31(40): 111727</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i40/111727.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i40.111727 |
