| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
MiR-451a targets mex-3 RNA binding family member C to regulate human hepatoblastoma G2 cell growth and metastasis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
De-Zheng Liu, Lin Wang, Shu-Kuan Yang, Zi-Jian Zhao, Yang-Yang Cui, Xue-Kai Zhao, Fan Zhang, Qing-Hai Guan and Lei Zhou |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 31640052 |
| Natural Science Foundation of Shandong Province, China |
No. ZR2019BH031 |
|
| Corresponding Author |
Lei Zhou, Full Professor, MD, PhD, Department of Biliary-Pancreatic Surgery, Binzhou Medical University Hospital, No. 661 Huanghe 2nd Road, Binzhou 256603, Shandong Province, China. dr_zhlei@163.com |
| Key Words |
Liver cancer; MiR-451a; Mex-3 RNA binding family member C; Proliferation; Migration |
| Core Tip |
Aberrant microRNAs (miRNAs) expression and associated pathways have been proved participate in regulation vast various physiologic and pathologic processed of different human cancers including liver cancer. In this study, we first provided evidence that miR-451a obviously down-regulated in hepatocellular carcinoma (HCC) tissues and tumor cell lines. Overexpression of miR-451a significantly inhibit human hepatoblastoma G2 (HepG2) cell proliferation, colony formation and migration. However, miR-451a were not participated in HCC cell apoptosis. Moreover, bioinformatic analysis showed that mex-3 RNA binding family member C (MEX3C) was target gene of miR-451a, which validated by reverse transcription-polymerase chain reaction and western blotting. Furthermore, rescue experiments confirmed that overexpression of MEX3C can inhibit the effect of miR-451a in HepG2. |
| Publish Date |
2025-09-23 06:49 |
| Citation |
<p>Liu DZ, Wang L, Yang SK, Zhao ZJ, Cui YY, Zhao XK, Zhang F, Guan QH, Zhou L. MiR-451a targets mex-3 RNA binding family member C to regulate human hepatoblastoma G2 cell growth and metastasis. <i>World J Clin Oncol</i> 2025; 16(9): 111742</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i9/111742.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i9.111742 |
