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Articles Published Processes
12/15/2025 9:46:09 AM | Browse: 11 | Download: 4
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Received |
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2025-07-09 04:33 |
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Peer-Review Started |
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2025-07-10 00:08 |
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First Decision by Editorial Office Director |
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2025-07-25 06:36 |
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Return for Revision |
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2025-07-25 06:36 |
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Revised |
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2025-08-06 12:12 |
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Publication Fee Transferred |
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2025-08-07 15:24 |
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Second Decision by Editor |
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2025-11-06 02:50 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-13 06:15 |
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Articles in Press |
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2025-11-13 06:15 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-03 06:46 |
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Publish the Manuscript Online |
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2025-12-15 09:46 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Basic Study |
| Article Title |
Oral Akkermansia muciniphila may ameliorates immune dysregulation in a murine model of streptozotocin-induced type 1 diabetes
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bao-Jiang Huang, Song Guo, Xiao-Ya Lin, Yan-Hong Li, Hua-Mei Ma, Jun Zhang and Qiu-Li Chen |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Qiu-Li Chen, Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Second Road, Guangzhou 510000, Guangdong Province, China. chenqiul@mail.sysu.edu.cn |
| Key Words |
Intestinal barrier; Autoimmune; Akkermansia muciniphila; Streptozotocin; Type 1 diabetes |
| Core Tip |
This study pioneers Akkermansia muciniphila (A. muciniphila) intervention evaluation in streptozotocin-induced type 1 diabetes mellitus (T1DM) mice. Despite no reversal of hyperglycemia or islet damage after short-term (3-day) oral administration, A. muciniphila ameliorated immune imbalance by enhancing intestinal barrier function (increased zonula occludens-1, decreased zonulin), suppressing pro-inflammatory cytokines (tumor necrosis factor-alpha, interferon-gamma), increasing anti-inflammatory interleukin-4 and regulatory T cells, modulating signaling pathways (reduced signal transducer and activator of transcription 1, suppressed nuclear factor kappa-B p65), and decreasing intestinal Actinobacteria abundance. These findings highlight A. muciniphila’s potential for immune regulation in established T1DM by gut barrier repair and microbial shifts. |
| Publish Date |
2025-12-15 09:46 |
| Citation |
Huang BJ, Guo S, Lin XY, Li YH, Ma HM, Zhang J, Chen QL. Oral Akkermansia muciniphila may ameliorates immune dysregulation in a murine model of streptozotocin-induced type 1 diabetes. World J Diabetes 2025; 16(12): 111771 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i12/111771.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i12.111771 |
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