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1/14/2026 8:09:14 AM | Browse: 4 | Download: 13
Publication Name World Journal of Diabetes
Manuscript ID 111808
Country China
Received
2025-07-10 08:15
Peer-Review Started
2025-07-11 00:28
First Decision by Editorial Office Director
2025-08-22 08:58
Return for Revision
2025-08-22 08:58
Revised
2025-09-20 16:50
Publication Fee Transferred
Second Decision by Editor
2025-12-02 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-12-02 07:31
Articles in Press
2025-12-02 07:31
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-01-04 02:06
Publish the Manuscript Online
2026-01-14 08:09
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Ophthalmology
Manuscript Type Observational Study
Article Title Association of serum and vitreous homocysteine and uric acid concentrations with post-vitrectomy prognosis in patients with proliferative diabetic retinopathy
Manuscript Source Unsolicited Manuscript
All Author List Qi-Bo Ran, Chun-Yan Lei, Sheng Gao, Xiang-Gang Yang, Fei-Peng Jiang and Mei-Xia Zhang
ORCID
Author(s) ORCID Number
Chun-Yan Lei http://orcid.org/0000-0003-4640-4601
Mei-Xia Zhang http://orcid.org/0000-0002-2633-6819
Funding Agency and Grant Number
Funding Agency Grant Number
Sichuan Provincial Science and Technology Support Project 2024YFFK0303
Corresponding Author Mei-Xia Zhang, Chief Physician, MD, Professor, Department of Ophthalmology, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan Province, China. zhangmeixia@scu.edu.cn
Key Words Proliferative diabetic retinopathy; Homocysteine; Uric acid; Pars plana vitrectomy; Prognosis; Optical coherence tomography; Optical coherence tomography angiography; Diabetic retinopathy
Core Tip This study demonstrates that vitreous homocysteine and uric acid are significantly elevated in patients with proliferative diabetic retinopathy, reflecting localized ocular pathology. Unlike their serum counterparts, elevated vitreous homocysteine specifically correlates with worse early visual acuity, progressive retinal nerve fiber layer thinning, and delayed microvascular impairment after pars plana vitrectomy, positioning it as a superior, compartment-specific predictor of multidimensional postoperative outcomes.
Publish Date 2026-01-14 08:09
Citation

Ran QB, Lei CY, Gao S, Yang XG, Jiang FP, Zhang MX. Association of serum and vitreous homocysteine and uric acid concentrations with post-vitrectomy prognosis in patients with proliferative diabetic retinopathy. World J Diabetes 2026; 17(1): 111808

URL https://www.wjgnet.com/1948-9358/full/v17/i1/111808.htm
DOI https://dx.doi.org/10.4239/wjd.v17.i1.111808
Full Article (PDF) WJD-17-111808-with-cover.pdf
STROBE Statement 111808-STROBE-statement.pdf
Manuscript File 111808_Auto_Edited_081745.docx
Answering Reviewers 111808-answering-reviewers.pdf
Audio Core Tip 111808-audio.m4a
Biostatistics Review Certificate 111808-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 111808-conflict-of-interest-statement.pdf
Copyright License Agreement 111808-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 111808-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 111808-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 111808-non-native-speakers.pdf
Peer-review Report 111808-peer-reviews.pdf
Scientific Misconduct Check 111808-scientific-misconduct-check.png
Scientific Editor Work List 111808-scientific-editor-work-list.pdf
CrossCheck Report 111808-crosscheck-report.pdf