| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Diabetic bone fragility through advanced glycation end product-collagen axis: Mechanisms and therapy of sodium glucose cotransporter 2 inhibitors
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Zhi-Peng Li, Cheng Luo, Xian-Mei Yu, Li-Ya Ye, Da Sun, Cheng-Zheng Duan, Shi-Yu Xu, Mei-Qi Zeng, Hui Xu, Zi-Yuan Peng, Peng Wang, Yao-Bin Wang, Wen-Jie Ruan, Meng-En Xue, Chang-Jiang Zhang and Dong-Juan He |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Clinical Medical Research Fund of the Zhejiang Medical Association |
2025ZYC-Z32 |
| Henan Provincial Key Research and Development Program |
231111311000 |
| Henan Provincial Science and Technology Research Project |
232102310411 |
| Clinical Medical Research Fund of the Zhejiang Medical Association |
2024ZYC-Z30 |
|
| Corresponding Author |
Dong-Juan He, Chief Physician, Deputy Director, Professor, Department of Endocrinology, The Second People’s Hospital of Quzhou, No. 338 Xin’an Avenue, Qujiang District, Quzhou 324002, Zhejiang Province, China. hedongjuan1247@wmu.edu.cn |
| Key Words |
Advanced glycation end products; Bone mineralization and microstructural heterogeneity; Bone mineral density; Diabetic bone fragility; High-resolution peripheral quantitative computed tomography; Nonenzymatic collagen cross-linking; Oxidative stress; Sodium-glucose cotransporter 2 inhibitors; Type I collagen |
| Core Tip |
This review highlights how advanced glycation end products (AGEs) exacerbate bone fragility in type 2 diabetes by cross-linking type I collagen and disrupting bone mineralization. These findings elucidate the AGE-type I collagen axis as a key pathogenic mechanism underlying the diabetic bone paradox. Emerging evidence suggests that sodium-glucose cotransporter 2 inhibitors may mitigate AGE-related bone damage beyond glycemic control. Targeting AGE formation, cross-linking, and receptor-mediated signaling offers novel therapeutic strategies to improve bone quality in diabetic patients. |
| Publish Date |
2025-10-15 09:03 |
| Citation |
<p>Li ZP, Luo C, Yu XM, Ye LY, Sun D, Duan CZ, Xu SY, Zeng MQ, Xu H, Peng ZY, Wang P, Wang YB, Ruan WJ, Xue ME, Zhang CJ, He DJ. Diabetic bone fragility through advanced glycation end product-collagen axis: Mechanisms and therapy of sodium glucose cotransporter 2 inhibitors. <i>World J Diabetes</i> 2025; 16(10): 111813</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i10/111813.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i10.111813 |
