| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Functional constipation in Thai infants and toddlers: The role of genetic-gut-brain interaction and fiber supplementation
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Kanticha Chatpermporn, Thitima Ngoenmak, Busara Charoenwat, Atchariya Chanpong, Hansa Sriphongphankul, Nipaporn Hanpitakpong and Palittiya Sintusek |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ratchadapiseksompotch Funds, Graduate Affairs, Faculty of Medicines, Chulalongkorn University, Bangkok, Thailand |
GA66/067 |
| The Royal college of Pediatricians of Thailand Research Funds |
no.RC.Ped.T.R.2023.2.2. |
|
| Corresponding Author |
Palittiya Sintusek, Associate Professor, MD, PhD, Center of Excellence in Thai Pediatric Gastroenterology, Hepatology and Immunology (TPGHAI), Division of Gastroenterology, Department of Pediatrics, King Chulalongkorn Memorial Hospital, Chulalongkorn University, 1873 Rama IV, Pathumwan, Bangkok 10330, Bangkok, Thailand. palittiya.s@chula.ac.th |
| Key Words |
Epidemiology; Dietary fiber; Defecation; Gut-brain axis; Fecal impaction |
| Core Tip |
To our knowledge, this nationwide study is the first to report the prevalence of functional constipation (FC) in Thai infants and toddlers using the validated Rome IV Diagnostic Questionnaire. FC affected 16.1% of children, demonstrating strong associations with age > 1 year, family history of constipation, fiber supplementation, and family-related stress. Findings highlight a complex interplay among genetic factors, dietary practices, and gut-brain interactions, particularly in the post-pandemic context while exploring the clinical value of fiber supplementation as a treatment. This study underscores the need for improved awareness and holistic management strategies to improve pediatric gastrointestinal health in Thailand. |
| Publish Date |
2026-03-06 08:56 |
| Citation |
Chatpermporn K, Ngoenmak T, Charoenwat B, Chanpong A, Sriphongphankul H, Hanpitakpong N, Sintusek P. Functional constipation in Thai infants and toddlers: The role of genetic-gut-brain interaction and fiber supplementation. World J Clin Pediatr 2026; 15(1): 111828 |
| URL |
https://www.wjgnet.com/2219-2808/full/v15/i1/111828.htm |
| DOI |
https://dx.doi.org/10.5409/wjcp.v15.i1.111828 |
