Publication Name	World Journal of Gastroenterology
Manuscript ID	11186
Country	Japan

Received	2014-05-08 09:32
Peer-Review Started	2014-05-08 13:17
To Make the First Decision	2014-05-29 19:12
Return for Revision	2014-06-04 11:20
Revised	2014-06-17 15:41
Second Decision	2014-07-22 16:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-07-22 18:18
Articles in Press	2014-07-22 18:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-30 19:15
Publish the Manuscript Online	2015-01-18 16:09

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Mutations of pre-core and basal core promoter before and after hepatitis B e antigen seroconversion
Manuscript Source	Unsolicited Manuscript
All Author List	Nozomi Kamijo, Akihiro Matsumoto, Takeji Umemura, Soichiro Shibata, Yuki Ichikawa, Takefumi Kimura, Michiharu Komatsu and Eiji Tanaka
Funding Agency and Grant Number	Funding Agency Grant Number Research grant from the Ministry of Health, Labor, and Welfare of Japan
Corresponding Author	Takeji Umemura, MD, PhD, Associate Professor, Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. tumemura@shinshu-u.ac.jp
Key Words	Seroconversion; Hepatitis B core-related antigen; pre-core; Basal core promoter; Mutation; Hepatitis B surface antigen; Hepatitis B virus DNA
Core Tip	The exact roles of pre-core (pre-C) and basal core promoter (BCP) mutations remain unclear before and after hepatitis B e antigen (HBeAg) seroconversion. Here, although the pre-C mutant became predominant in the HBeAg seroconversion group during follow-up, the proportion of the BCP mutation did not change. Hepatitis B virus (HBV) viral markers were significantly higher in patients without the mutations in an HBeAg positive status. HBV DNA and hepatitis B surface antigen levels were higher in patients with the pre-C mutation in an anti-HBe positive status. Taken together, the association of the pre-C mutation on viral load appears to be opposite before and after HBeAg seroconversion in patients with HBV infection.
Publish Date	2015-01-18 16:09
Citation	Kamijo N, Matsumoto A, Umemura T, Shibata S, Ichikawa Y, Kimura T, Komatsu M, Tanaka E. Mutations of pre-core and basal core promoter before and after hepatitis B e antigen seroconversion. World J Gastroenterol 2015; 21(2): 541-548
URL	http://www.wjgnet.com/1007-9327/full/v21/i2/541.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i2.541

Full Article (PDF)	WJG-21-541.pdf
Full Article (Word)	WJG-21-541.doc
Manuscript File	11186-Review.docx
Answering Reviewers	11186-Answering reviewers.pdf
Copyright License Agreement	11186-Copyright assignment.pdf
Peer-review Report	11186-Peer review(s).pdf
Scientific Misconduct Check	11186-CrossCheck.jpg
Scientific Editor Work List	11186-Scientific editor work list.pdf