BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
2/9/2015 5:58:00 PM | Browse: 1001 | Download: 1269
 |
Received |
|
2014-05-08 10:36 |
|
Peer-Review Started |
|
2014-05-08 13:27 |
|
To Make the First Decision |
|
2014-06-27 17:47 |
|
Return for Revision |
|
2014-07-02 17:29 |
|
Revised |
|
2014-07-04 19:28 |
|
Second Decision |
|
2014-09-19 08:51 |
 |
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Company Editor-in-Chief |
|
2014-09-19 09:37 |
|
Articles in Press |
|
2014-09-19 10:23 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
2014-10-16 15:04 |
|
Typeset the Manuscript |
|
2015-01-22 14:58 |
|
Publish the Manuscript Online |
|
2015-02-09 17:58 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Autobiography |
| Article Title |
S-phase arrest after vincristine treatment may promote hepatitis B virus replication
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lei Xu, Zeng Tu, Ge Xu, Jie-Li Hu, Xue-Fei Cai, Xing-Xing Zhan, Yu-Wei Wang, Yuan Huang, Juan Chen and Ai-Long Huang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81201282 |
| National Natural Science Foundation of China |
30901280 |
| Chongqing Natural Science Foundation |
cstc2012jjA10047 |
| Doctoral Fund of Ministry of Education of China |
20125503120004 |
|
| Corresponding Author |
Ai-Long Huang, Professor, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, No. 1 Yixueyuan Road, Chongqing 400016, China. ahuang@cqu.edu.cn |
| Key Words |
Viral reactivation; Cytotoxic chemotherapy; Cell cycle arrest; Proliferation; Hepatitis B virus |
| Core Tip |
Hepatitis B virus (HBV) reactivation is an emerging clinical challenge for HBV carriers receiving anti-cancer chemotherapy. However, the mechanism for the sharp increase in viral replication in the early stages of chemotherapy is still unclear. In this research, we found that vincristine, which is a cytotoxic drug, had a direct stimulatory effect on HBV replication without the involvement of immune factors and that vincristine induced cell cycle arrest; cell proliferation inhibition may be conducive to viral replication, and this may be a novel mechanism of HBV reactivation following cytotoxic chemotherapy. |
| Publish Date |
2015-02-09 17:58 |
| Citation |
Xu L, Tu Z, Xu G, Hu JL, Cai XF, Zhan XX, Wang YW, Huang Y, Chen J, Huang AL. S-phase arrest after vincristine treatment may promote hepatitis B virus replication. World J Gastroenterol 2015; 21(5): 1498-1509 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i5/1498.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i5.1498 |
© 2004-2024 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
