Publication Name	World Journal of Gastroenterology
Manuscript ID	11188
Country	China

Received	2014-05-08 10:36
Peer-Review Started	2014-05-08 13:27
First Decision by Editorial Office Director
Return for Revision	2014-07-02 17:29
Revised	2014-07-04 19:28
Publication Fee Transferred
Second Decision by Editor	2014-09-19 08:51
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-09-19 09:37
Articles in Press	2014-09-19 10:23
Edit the Manuscript by Language Editor	2014-10-16 15:04
Typeset the Manuscript	2015-01-22 14:58
Publish the Manuscript Online	2015-02-09 17:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Autobiography
Article Title	S-phase arrest after vincristine treatment may promote hepatitis B virus replication
Manuscript Source	Unsolicited Manuscript
All Author List	Lei Xu, Zeng Tu, Ge Xu, Jie-Li Hu, Xue-Fei Cai, Xing-Xing Zhan, Yu-Wei Wang, Yuan Huang, Juan Chen and Ai-Long Huang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81201282 National Natural Science Foundation of China 30901280 Chongqing Natural Science Foundation cstc2012jjA10047 Doctoral Fund of Ministry of Education of China 20125503120004
Corresponding Author	Ai-Long Huang, Professor, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, No. 1 Yixueyuan Road, Chongqing 400016, China. ahuang@cqu.edu.cn
Key Words	Viral reactivation; Cytotoxic chemotherapy; Cell cycle arrest; Proliferation; Hepatitis B virus
Core Tip	Hepatitis B virus (HBV) reactivation is an emerging clinical challenge for HBV carriers receiving anti-cancer chemotherapy. However, the mechanism for the sharp increase in viral replication in the early stages of chemotherapy is still unclear. In this research, we found that vincristine, which is a cytotoxic drug, had a direct stimulatory effect on HBV replication without the involvement of immune factors and that vincristine induced cell cycle arrest; cell proliferation inhibition may be conducive to viral replication, and this may be a novel mechanism of HBV reactivation following cytotoxic chemotherapy.
Publish Date	2015-02-09 17:58
Citation	Xu L, Tu Z, Xu G, Hu JL, Cai XF, Zhan XX, Wang YW, Huang Y, Chen J, Huang AL. S-phase arrest after vincristine treatment may promote hepatitis B virus replication. World J Gastroenterol 2015; 21(5): 1498-1509
URL	http://www.wjgnet.com/1007-9327/full/v21/i5/1498.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i5.1498

Full Article (PDF)	WJG-21-1498.pdf
Full Article (Word)	WJG-21-1498.doc
Manuscript File	11188-Review.doc
Answering Reviewers	11188-Answering reviewers.pdf
Copyright License Agreement	11188-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	11188-Language certificate.pdf
Peer-review Report	11188-Peer review.pdf
Scientific Misconduct Check	11188-CorssCheck.jpg
Scientific Editor Work List	11188-Scientific editor work list.pdf