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Articles Published Processes
1/9/2026 9:47:33 AM | Browse: 87 | Download: 230
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Received |
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2025-07-14 04:19 |
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Peer-Review Started |
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2025-07-14 04:20 |
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First Decision by Editorial Office Director |
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2025-08-20 07:26 |
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Return for Revision |
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2025-08-20 07:26 |
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Revised |
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2025-09-15 17:47 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-13 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-13 08:15 |
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Articles in Press |
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2025-11-13 08:15 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-30 03:59 |
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Publish the Manuscript Online |
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2026-01-09 09:47 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Minireviews |
| Article Title |
Molecular hydrogen therapy in musculoskeletal conditions: An evidence-based review and critical analysis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Naveen Jeyaraman, Madhan Jeyaraman, Swaminathan Ramasubramanian, Shrideavi Murugan, Arulkumar Nallakumarasamy and Sathish Muthu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Madhan Jeyaraman, MD, PhD, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Poonamalle High Road, Velappanchavadi, Chennai 600077, Tamil Nādu, India. madhanjeyaraman@gmail.com |
| Key Words |
Molecular hydrogen; Musculoskeletal disorders; Oxidative stress; Anti-inflammation; Clinical evidence |
| Core Tip |
Molecular hydrogen therapy exhibits potent antioxidant, anti-inflammatory, and cytoprotective effects across diverse musculoskeletal conditions. This review synthesizes evidence from 45 studies - spanning osteoarthritis, rheumatoid arthritis, muscle damage, chronic pain, and atrophy - highlighting promising symptomatic relief and mechanistic plausibility. However, variability in delivery methods, sample sizes, and endpoints demands standardized trials with biomarker-driven designs to validate molecular hydrogen’s efficacy and guide clinical integration. |
| Publish Date |
2026-01-09 09:47 |
| Citation |
Jeyaraman N, Jeyaraman M, Ramasubramanian S, Murugan S, Nallakumarasamy A, Muthu S. Molecular hydrogen therapy in musculoskeletal conditions: An evidence-based review and critical analysis. World J Orthop 2026; 17(1): 111911 |
| URL |
https://www.wjgnet.com/2218-5836/full/v17/i1/111911.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v17.i1.111911 |
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