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Articles Published Processes
9/25/2025 3:33:10 AM | Browse: 167 | Download: 268
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Received |
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2025-07-16 13:26 |
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Peer-Review Started |
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2025-07-16 13:26 |
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First Decision by Editorial Office Director |
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2025-08-08 09:36 |
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Return for Revision |
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2025-08-08 09:36 |
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Revised |
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2025-08-21 16:12 |
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Publication Fee Transferred |
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2025-08-25 10:02 |
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Second Decision by Editor |
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2025-09-10 02:46 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-10 06:46 |
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Articles in Press |
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2025-09-10 06:46 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-22 02:09 |
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Publish the Manuscript Online |
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2025-09-25 03:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Prognostic value of serum alpha-fetoprotein kinetics in liver failure on artificial liver support
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei-Bo Guo, Lu-Yao Wang, Xi-Ju Guo, Jing Yang, Wen Li, Fa-Yao Shen, Yu-Ting Li, Jin-Hui Yang and Wen-Lin Tai |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82160106 |
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| Corresponding Author |
Jin-Hui Yang, Chief Physician, Full Professor, Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, No. 374 Dianmian Avenue, Wuhua District, Kunming 650101, Yunnan Province, China. yangjinhui@kmmu.edu.cn |
| Key Words |
Liver failure; Artificial liver support system; Plasma exchange; Alpha-fetoprotein; Liver function; Survival rate; Prognostic prediction |
| Core Tip |
This study establishes that baseline alpha-fetoprotein (AFP) stratification (< 100 ng/mL, 100-200 ng/mL, > 200 ng/mL) in liver failure patients receiving plasma exchange-based artificial liver support systems predicts regenerative capacity and clinical outcomes. High-AFP patients (> 200 ng/mL) baseline AFP levels demonstrated improved liver function recovery, fewer complications, and required fewer treatment sessions compared to those with lower levels. Critically, three-month survival was dose-dependent, with baseline AFP > 200 ng/mL providing excellent prognostic discrimination. Serial AFP monitoring enables precision artificial liver support systems therapy by identifying patients with high endogenous regenerative potential. |
| Publish Date |
2025-09-25 03:33 |
| Citation |
Guo WB, Wang LY, Guo XJ, Yang J, Li W, Shen FY, Li YT, Yang JH, Tai WL. Prognostic value of serum alpha-fetoprotein kinetics in liver failure on artificial liver support. World J Gastroenterol 2025; 31(37): 111914 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i37/111914.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i37.111914 |
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