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Articles Published Processes
10/27/2025 8:08:12 AM | Browse: 167 | Download: 347
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Received |
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2025-07-14 03:07 |
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Peer-Review Started |
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2025-07-14 03:07 |
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First Decision by Editorial Office Director |
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2025-07-18 08:04 |
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Return for Revision |
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2025-07-18 08:04 |
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Revised |
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2025-07-29 16:12 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-09-16 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-16 03:27 |
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Articles in Press |
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2025-09-16 03:27 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-21 01:51 |
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Publish the Manuscript Online |
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2025-10-27 08:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Prognostic role of histone deacetylase 10 in colorectal cancer: Strengths and gaps
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ali Afzal, Chatchai Muanprasat and Muhammad Babar Khawar |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Chatchai Muanprasat, Professor, Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road/Phutthamonthon 4 Road, Bangpla 10540, Bangplee, Thailand. chatchai.mua@mahidol.ac.th |
| Key Words |
Histone deacetylase 10; Colorectal cancer; Tumor microenvironment; Immunotherapy resistance; P53-programmed death ligand 1 axis |
| Core Tip |
Histone deacetylase 10 (HDAC10) plays a multifaceted role in colorectal cancer by modulating immune evasion, chemoresistance, and transcriptional regulation. Its suppression influences CD8⁺ T cell activation, enhances p53 expression, and reduces programmed death ligand 1 levels, suggesting critical involvement in tumor-immune interactions. Selective HDAC10 inhibition, unlike pan-HDAC blockade, may offer targeted therapeutic benefit, particularly in microsatellite-stable tumors. Further in vivo studies and mechanistic dissection of HDAC10-p53-programmed death ligand 1 signaling are essential to harness its full potential in reshaping the tumor microenvironment and improving immunotherapy outcomes. |
| Publish Date |
2025-10-27 08:08 |
| Citation |
Afzal A, Muanprasat C, Khawar MB. Prognostic role of histone deacetylase 10 in colorectal cancer: Strengths and gaps. World J Gastroenterol 2025; 31(40): 111951 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i40/111951.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i40.111951 |
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