2/12/2026 11:20:22 AM | Browse: 1 | Download: 0
| Publication Name | World Journal of Hepatology |
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| Manuscript ID | 111962 |
| Country | Germany |
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| ISSN | 1948-5182 (online) |
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| Open Access | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright | © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Gastroenterology & Hepatology | ||||||||||||||||||||||||||||||
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| Manuscript Type | Observational Study | ||||||||||||||||||||||||||||||
| Article Title | Performance of three clinical scores for steatosis and steatohepatitis and thei interaction with metabolic syndrome in obese individuals | ||||||||||||||||||||||||||||||
| Manuscript Source | Invited Manuscript | ||||||||||||||||||||||||||||||
| All Author List | Giovani Schulte Farina, Bárbara Brambilla, Emanuelle Mendonça Pandolfo, Laura Kalil Nader Lazzaretti, Stéfano Mateus Schio Kuiava, Ana Maria Graciolli, Vitória Maria Kriger, Carlos Henrique Dal Bem Fistarol, Augusto Cardoso Sgarioni, Henrique Prataviera Giovanardi, Aline Caldart Tregnago, Floriano Riva, Cassiano da Silva Scholze, Daniel Cecconi Agostini, Bruno Dellamea, Arturo Tamayo, Tiago Lemos Cerqueira, Jonathan Soldera and Ben Min-Woo Illigens | ||||||||||||||||||||||||||||||
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| Corresponding Author | Giovani Schulte Farina, MD, Master's Program in Clinical Research, Dresden International University, Freiberger Str. 37, Dresden 01067, Saxony, Germany. farina.giovanimd@gmail.com | ||||||||||||||||||||||||||||||
| Key Words | Metabolically-dysfunction-associated steatotic liver disease; Liver steatosis; Steatohepatitis; Obesity; Clinical scores | ||||||||||||||||||||||||||||||
| Core Tip | This study evaluated and optimized the diagnostic performance of three clinical scores— Non-alcoholic fatty liver disease Liver Fat Score, Hepatic Steatosis Index, and Fatty Liver Index—for detecting steatosis and steatohepatitis in obese individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). Using liver biopsy as a reference, we showed that standard thresholds performed poorly, but accuracy improved with optimized cut-offs. Metabolic syndrome status did not affect score performance significantly, suggesting that these tools can be applied across the MASLD metabolic spectrum. Our findings provide practical insights into improving non-invasive diagnosis in high-risk populations, where early detection is essential but challenging. | ||||||||||||||||||||||||||||||
| Publish Date | 2026-02-12 11:20 | ||||||||||||||||||||||||||||||
| Citation | Farina GS, Brambilla B, Pandolfo EM, Lazzaretti LKN, Kuiava SMS, Graciolli AM, Kriger VM, Fistarol CHDB, Sgarioni AC, Giovanardi HP, Tregnago AC, Riva F, Scholze CDS, Agostini DC, Dellamea B, Tamayo A, Cerqueira TL, Soldera J, Illigens BMW. Performance of three clinical scores for steatosis and steatohepatitis and thei interaction with metabolic syndrome in obese individuals. World J Hepatol 2026; 18(2): 111962 |
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| URL | https://www.wjgnet.com/1948-5182/full/v18/i2/111962.htm | ||||||||||||||||||||||||||||||
| DOI | https://dx.doi.org/10.4254/wjh.v18.i2.111962 |
| Full Article (PDF) | WJH-18-111962-with-cover.pdf |
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| STROBE Statement | 111962-STROBE-statement.pdf |
| Manuscript File | 111962_Auto_Edited_094850.docx |
| Answering Reviewers | 111962-answering-reviewers.pdf |
| Audio Core Tip | 111962-audio.mp3 |
| Biostatistics Review Certificate | 111962-biostatistics-statement.pdf |
| Conflict-of-Interest Disclosure Form | 111962-conflict-of-interest-statement.pdf |
| Copyright License Agreement | 111962-copyright-assignment.pdf |
| Signed Informed Consent Form(s) or Document(s) | 111962-informed-consent-statement.pdf |
| Institutional Review Board Approval Form or Document | 111962-institutional-review-board-statement.pdf |
| Non-Native Speakers of English Editing Certificate | 111962-non-native-speakers.pdf |
| Supplementary Material | 111962-supplementary-material.pdf |
| Peer-review Report | 111962-peer-reviews.pdf |
| Scientific Misconduct Check | 111962-scientific-misconduct-check.png |
| Scientific Editor Work List | 111962-scientific-editor-work-list.pdf |
| CrossCheck Report | 111962-crosscheck-report.pdf |