BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
12/5/2025 11:28:06 AM | Browse: 120 | Download: 268
 |
Received |
|
2025-07-15 11:20 |
|
Peer-Review Started |
|
2025-07-15 11:20 |
|
First Decision by Editorial Office Director |
|
2025-07-28 08:28 |
|
Return for Revision |
|
2025-07-28 08:28 |
|
Revised |
|
2025-08-13 07:48 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2025-11-13 02:44 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2025-11-13 07:10 |
|
Articles in Press |
|
2025-11-13 07:10 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2025-11-19 09:34 |
|
Publish the Manuscript Online |
|
2025-12-05 11:28 |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
L-arginine-induced chronic pancreatitis in mice: Evaluating effects of pirfenidone and simvastatin
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Rajiv Mehta, Archi Patel, Bhavin Vyas, Bhargavi Desai, Dhvani Adhvaryu, Prakash Sojitra and Simple Bhuptani |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Rajiv Mehta, Department of Gastroenterology, SIDS Hospital and Research Centre, Surat Institute of Digestive Sciences, Khatodra-bamroli road, near Shell Petrol pump, Surat 395002, Gujarat, India. rmgastro@yahoo.com |
| Key Words |
Pirfenidone; Simvastatin; Chronic pancreatitis; L-arginine; Oxidative stress |
| Core Tip |
Combination therapy with pirfenidone and simvastatin significantly attenuated inflammation, fibrosis, and oxidative stress in an L-arginine-induced mouse model of chronic pancreatitis. The synergistic action led to reduced tumor necrosis factor-alpha, transforming growth factor-beta 1, and lipid peroxidation levels, along with a preservation of pancreatic tissue architecture. The combination therapy also enhanced antioxidant defense as evidenced by increased glutathione peroxidase 1 activity, indicating mitigation of oxidative damage. These findings highlighted a promising strategy targeting multiple pathological pathways, namely inflammatory, fibrotic, and oxidative stress mechanisms, and supported further evaluation of this combination in translational and clinical studies for chronic pancreatitis. |
| Publish Date |
2025-12-05 11:28 |
| Citation |
Mehta R, Patel A, Vyas B, Desai B, Adhvaryu D, Sojitra P, Bhuptani S. L-arginine-induced chronic pancreatitis in mice: Evaluating effects of pirfenidone and simvastatin. World J Gastrointest Pharmacol Ther 2025; 16(4): 111977 |
| URL |
https://www.wjgnet.com/2150-5349/full/v16/i4/111977.htm |
| DOI |
https://dx.doi.org/10.4292/wjgpt.v16.i4.111977 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
